Digital PCR also had a nice growth when excluding the RainDance sales and our process media product line which can fluctuate on a quarterly basis, had a very strong quarter. Excluding process media sales, the Life Science business grew about 5.5% year-over-year on a currency neutral basis. On a geographic basis, Life Science currency-neutral sales were strong across all three regions and most notable in the Americas. Sales of Clinical Diagnostics products in the quarter were $334.1 million compared to $350.8 million in Q1 of 2018 which is a 4.8% decline on a reported basis and less than 1% decline on a currency neutral basis. Excluding last year's tough compare of the royalty settlement, the diagnostics business grew about 1% year-over-year on a currency neutral basis. Despite a steady growth, it is important to know that placements of our key diagnostic systems showed consistent growth during the first quarter of 2019 versus Q1 of 2018.

During the quarter, the Diagnostics Group posted solid growth in the Americas, across all the product areas and of note growth in blood typing and in autoimmune testing products. These geographic growth was somewhat offset by a weaker quarter in parts of EMEA and in Asia. The decline in Asia was associated with order timing this quarter and a tough compare with Q1 of 2018. Overall, our outlook for Asia remains positive. The reported gross margin for the first quarter of 2019 was 56.3% on a GAAP basis and compares to 54.8% in Q1 of 2018.

The current quarter gross margin benefited from an Escrow release of $7.4 million related to an acquisition from 2011 within the Life Science group. The gross margin also benefited from improved logistics cost and inventory reserves. The improvement was partially offset by product mix and higher service costs. Amortization related to prior acquisitions recorded in cost of goods sold was $3.7 million compared to $4.8 million in Q1 of 2018.

SG&A expenses for Q1 of 2019 were $207.6 million or 37.5% of sales compared to 37.9% in Q1 of 2018. Total amortization related to acquisitions recorded in SG&A for the quarter was $1.7 million versus $2.1 million in Q1 of 2018. Research and development expense in Q1 was $47.6 million or 8.6% of sales compared to $49.4 million or 9% in Q1 of 2018. Looking below the operating line, the change in share market value of the equity securities holdings added $1 billion and $59 million of income to the reported results, and it substantially related to the holdings of the shares of Sartorius AG.

Also during the quarter. interest and other income resulted in net other income of $11.4 million compared to $4.1 million income last year. Q1 of 2019 includes $15.7 million of gross dividend income from Sartorius which was declared this year in March and was paid in April. In 2018, the dividend was declared and paid in the second quarter. Remember that in the first quarter of 2018, other income included $9.2 million for the divestiture of a small product line and the sale of surplus land in Europe.

The effective tax rate used in Q1 of 2019 was 23.2% and compares to 24% in Q1 of 2018. Reported net income for the first quarter was $865.2 million and diluted earnings per share for the quarter were $28.74. The increase in net income and earnings per share versus last year is substantially related to the valuation of the Sartorius Holding.

Moving on to the non-GAAP results. Looking at our results on a non-GAAP basis, we have excluded certain atypical and unique items that impacted both the gross and operating margins, as well as other income.These items are detailed in the reconciliation table in the press release. Looking at the non-GAAP results for the first quarter in cost of goods sold . We have excluded $3.7 million of amortization of purchased intangibles, $7.4 million Escrow release related to our prior acquisition within the Life Science group and a small restructuring adjustment.

These adjustments move the gross margin for the first quarter from 56.3% to 55.6. These non-GAAP gross margin compares to a non-GAAP gross margin of 55.7% in Q1 of 2018. The non-GAAP SG&A in the first quarter of 2019 was 36.4% an improvement versus 37.1% in Q1 of 2018. In SG&A, on a non-GAAP basis, we have excluded amortization of purchased intangibles of $1.7 million, legal related expenses of $4.4 million, acquisition related benefits of $365,000 and a small restructuring costs.

In R&D, we have excluded a small amount of restructuring costs. The non-GAAP R&D in Q1 was 8.6%, which is in line with our expectation. The cumulative sum of these non-GAAP adjustments result in moving this quarterly operating margin from 10.2% on a GAAP basis to 10.5% on a non-GAAP basis.

These non-GAAP operating margin compares to a non-GAAP operating margin in Q1 of 2018 of 9.7%. We have also excluded certain items below the operating line which are the increase in value of the Sartorius equity holdings of $1 billion and $69 million as well as $440,000 associated with venture investments and other nonrecurring items. The non-GAAP effective stocks rate for the quarter was 28.5%, this higher tax rate reflects a change in geographic mix of the profitability, however, we still expect the full-year non-GAAP effective tax rate to be between 27% and 28%. And finally, non-GAAP net income and earnings per share for the first quarter of 2019 were $49.6 million and $1.65 per share compared to $35.4 million and $1.17 per share in Q1 of 2018.

We estimate that the Sartorius dividend net of an estimation of it's stocks provision totals $0.40. The estimated EPS benefit of $0.40 shift from Q2 to Q1 and Sartorius may continue to declare future annual dividend distributions in the first calendar quarter of each year.

Moving onto the balance sheet, as of March 31st, total cash and short-term investments were $865 million compared to $850 million at the end of 2018. The first quarter historically has tended to be a heavy cash use quarter as we typically pay the annual bonuses and commissions as well as annual software and IT related maintenance expenses. Also during the quarter, we completed an acquisition of a small company in the Life Science group that will expand our suite of genomic reagent offerings.

In the first quarter, we adopted the new accounting standard related to leases which requires us to recognize most leases as assets and liabilities on the balance sheet. You will note at $222 million addition to the balance sheet of right-of-use assets and associated liabilities which are included in other current liabilities and in other long-term liabilities. These balances primarily represent our operating lease obligations for the duration of the global facilities and other leases. The adoption of the standard has a minimal effect to the income statement. For the first quarter of 2019, net cash generated from operations was $43 million which compares to $40 million in Q1 of 2018. This improvement reflects the higher operating profits partially as a result of a disciplined cost control. The adjusted EBITDA for the first quarter of 2019 which includes the Sartorius dividend was $101.7 million or 18.4% of sales. The estimated adjusted EBITDA in Q1 of 2019 and excluding the Sartorius dividend was about 15.5% the adjusted EBITDA in the first quarter of 2018 was $81.1 million or about 14.7% of sales.

Net capital expenditures for the first quarter of 2019 were $23.6 million or 4.3% of sales. Our expectation for the full year CapEx spend remains in the range of $110 million to $120 million and depreciation and amortization for the quarter was $32.9 million. We are currently on track with the annual guidance that was provided during the last call. And with this Norman, do you have anything you would like to say before we open the call for the questions?

Norman Schwartz -- Chairman of the Board, President and Chief Executive Officer

Sure. I think Ilan covered the quarter well. I just wanted to say that it's great to have both Ilan and Andy, Andy last on Board, both recently joined us and they both bring a wealth of experience and fresh perspectives to Bio Rad. As you may know, Ilan's background is in accounting and finance and he has spent most of his career in the semiconductor industry mostly with global companies. Andy, is rooted in the biological sciences and over the years he has progressed through product and general management at some recognizable names like Applied Biosystems, BD and Affymetrix and bringing with him a wealth of industry and operational experience. I think they both joined us as we're off to a good start for the year. And the organization looks forward to their contributions and with that, Jimmy, I think we'll open up the line to take your questions.

Questions and Answers:

Operator

(Operator Instructions) Our first question comes from Michael Sarcone with Deutsche Bank. Your line is now open.

Michael Sarcone -- Deutsche Bank -- Analyst

Thanks, good afternoon, this is Mike Sarcone on for Dan Leonard. Just first on the Life Sciences business, you called out particularly strength in the Americas. Can you give us some more granularity on what you saw in APAC and Europe?

Annette Tumolo -- Executive Vice President, President, Life Science Group

Hi, this is Annette. So we saw good growth across all our geographies, we called the Americas out because they were particularly strong. So I don't have anything bad to say about growth in Europe and EMEA and Asia. They are growing across all of our key product areas.

Michael Sarcone -- Deutsche Bank -- Analyst

Got it, thanks. And just one on the Clinical Diagnostics business. You gave a positive mentioned to autoimmune and blood typing. Can you maybe delve into any areas where you saw particular weakness just to get some granularity there?

Ronald Hutton -- Vice President and Treasurer

Mike, you're looking for a year-over-year increase?

Michael Sarcone -- Deutsche Bank -- Analyst

No, well, you had mentioned, you called out the positives in the quarter for clinical diagnostic. I was just curious if there was anything that stood out as being particularly weak in the quarter. And if you could kind of talk to that.

Ronald Hutton -- Vice President and Treasurer

Particularly weak in the quarter?

Michael Sarcone -- Deutsche Bank -- Analyst

Yes.

Ronald Hutton -- Vice President and Treasurer

Well, I think in the in the earlier narrative, we talked a little bit about Asia and parts of Europe being a little bit weak Asia because of sort of the ordering lumpiness and there were certain parts of Europe, I'd say probably non-core Europe that were weaker. And we did see some growth in quality control and diabetes on a global level but we didn't highlight that because it wasn't as strong as both the BioPlex autoimmune business and blood typing.

Norman Schwartz -- Chairman of the Board, President and Chief Executive Officer

And let me add to that also for Asia, specifically, we believe it's a timing issue and it's not kind of a sustained weakness that we see so far.

Michael Sarcone -- Deutsche Bank -- Analyst

Got it. Thank you. And last one for me. Are you still expecting EMEA on the clinical diagnostics side, to return to growth this year?

Ronald Hutton -- Vice President and Treasurer

Yes. We did actually see some growth in quarter one. I think we've mentioned over the last few calls, if you go back to couple of years, there was some consolidation in Europe and assets load growth and then we talked at our last earnings call about EMEA having worked through the D3 transition for SAP that seems to be continuing and they did show growth overall for this quarter, which was encouraging.

Michael Sarcone -- Deutsche Bank -- Analyst

Okay, thank you.

Ronald Hutton -- Vice President and Treasurer

Thank you.

Operator

Thank you. And our next question comes from Brandon Couillard with Jefferies. Your line is now open.

Brandon Couillard -- Jefferies -- Analyst

Thanks, good afternoon. I actually like to start with Andy. I'm curious if there are any similarities, you can draw from your time at Affymetrix where I think you took operating margins up something like 600 basis points over time that you can apply and that adhere at Bio-Rad, What are some of your near-term priorities as you sort of take over this CEO role in some of the biggest opportunities you see near term?

Andrew Last -- Executive Vice President, Chief Operating Officer

Thank you, Brandon. So 600 basis points for that. Okay. Well, I think, the main comments I would make is that was really a question of probably managing the portfolio of the company and applying the resource where the biggest growth opportunities were. When I come into Bio Rad, I mean I'm on a couple of weeks and it's very early. I've got to -- fully understand the business and the profile of the business, but it's got a similar mix to Affymetrix and I feel confident that we can apply the same principles as we move forward.

Brandon Couillard -- Jefferies -- Analyst

All right, super and then maybe one for you, Ilan it's early but based on your first few weeks at the company, any reason to back off the 2020 targets? How would you just sort of describe your level of comfort with those that were established sort of by your predecessor? And any thoughts as to how you might be able to use the balance sheet more sensibly and do you think of carrying $400 million to $500 million of net cash is an optimal position for the balance sheet.

Ilan Daskal -- Executive Vice President, Chief Financial Officer

Yes, sure. Thanks, Brendan. So let me start with the 2020 target. I did have kind of a talk down and look at it and at the first kind of conclusion, I think that is -- is a reasonable target to achieve and that's by the end of 2020. We have several initiatives within the Company, several that are focused in the SG&A and in gross margin expansion. And Andy and I are going to look into those initiatives on a bottom-up basis and we're going to dive into each one of them. But overall, again it is targeted, I believe we can achieve by the end of 2020.

Going back to your second question regarding the capital allocation model. So when you look at it, we have a $250 million buyback program right now, we did about 49 so far. And when you think about the inorganic activities, as an example the acquisition that we did this quarter. We continue to have the same kind of approach of either at tuck-in technology acquisitions or IP or alternatively acquisitions with nice cash flow this year in order to augment the free cash flow overall and at least for the time being, we think this is the best use of the overall capital allocation model that will deploy.

Brandon Couillard -- Jefferies -- Analyst

Okay and then what are your net -- could you speak to in sort of the demand trends you're seeing in the ddPCR business any moderation in growth there at all? And what are some of the key drivers and applications that are driving adoption of that system and any chance you could share with us the update on where the global installed base stands now? Thank you.

Annette Tumolo -- Executive Vice President, President, Life Science Group

I can probably answer some of those questions, Brandon. So we continue to see really good adoption for liquid biopsy application. It's is growing across all geographies. So we are very happy about that and we see really strong sales into the biopharma segment, both in discovery and in the QC and manufacturing and as people are manufacturing some of these newer cell-based drugs. So those are 2 areas that continue to drive good growth for us. Tell me what your other question was? We don't really talk about our installed base, but to say it's growing, and we expect this year to really continue the consumable pull through on all of those products as well.

Brandon Couillard -- Jefferies -- Analyst

Okay. And then maybe last one for John, perhaps a little bit of a slower start arguably some timing dynamics in there in diagnostics in Asia but you still expect that business to grow 3% to 4% for the year and then specifically on the blood typing business, how do you think your growth stacks up relative to that level of the market? And could you sort of speak to perhaps your competitive win rate if you launch some of these newer platforms in the US? Thank you.

Ronald Hutton -- Vice President and Treasurer

Yes. I'll start with the first question and Brandon overall guidance and confidence for us at both the group level and in Asia is fine we would stick with that.

Blood typing continues to be strong, we don't really talk about competitive shares but we grew the business nicely in the first quarter. Adoption in the U.S. has been really good with the recent FDA approvals of the IH24 and then just last month IH500, we expect that to improve. We always start the medium volume market was the largest part of the market in the United States and IH500 is particularly well suited for that, so we continue to see good prospects for that business overall.

Brandon Couillard -- Jefferies -- Analyst

Very good. Thank you.

Ronald Hutton -- Vice President and Treasurer

Thank you, Brendan.

Operator

Thank you. And our next question comes from Patrick Donnelly with Goldman Sachs. Your line is now open.

Patrick Donnelly -- Goldman Sachs -- Analyst

Great, thanks. Maybe just one on the Life Science business, you obviously put up a great quarter. Maybe just talk through the magnitude of the beat there the durability of the growth, I know the guidance is for more kind of 5% to 6% type growth, nice double-digit growth to start the year, it doesn't seem like the outlook changed much but maybe just walk us through the dynamics. Is there any pull forward dynamic or any reason to think that the growth will slow materially again to get closer to that guidance range?

Annette Tumolo -- Executive Vice President, President, Life Science Group

We were happy that we had really strong growth across all of our core businesses and some of our newer businesses and good growth from process chromatography resins and that's one of those businesses where we can see fluctuations quarter-to-quarter in customer orders and we don't like to but we call that a lumpy business. So in the first quarter, we did have some pull through of orders that we expected to come in Q2, we got them in Q1. So I think that that moderates some of our expectations moving forward.

Patrick Donnelly -- Goldman Sachs -- Analyst

Okay, makes sense. And then the Ilan maybe some on the margin story, particularly this year seems a little ahead of schedule. We had it a little more back half-weighted. So can you just talk through what came in a little ahead of expectations on the margin side, what levers you guys been able to pull again maybe a little ahead of expectations?

Ilan Daskal -- Executive Vice President, Chief Financial Officer

Yes. So first let's recap the -- On a non-GAAP basis, the margin was about 55.6, which is about flat year-over-year. When you back out the RainDance revenue as well as the royalties from last year, you get a pickup of about a point or so. A lot of that pickup was in outcome of the initiative from last year. If you recall, the consolidation of the warehouses and logistics and supply chain kind of improvement and that contributed a lot of you know, of the incremental kind of margin and obviously process from was the other piece for this quarter.

Patrick Donnelly -- Goldman Sachs -- Analyst

Okay. And then last one from me just on the softness in Asia. Can you just give a bit more color on the order timing that things slip into 2Q that you've already recognized and expect to see a catch up on revs in 2Q or was it more uncertain in terms of the timing there?

John Hertia -- Executive Vice President, President

Its John Hertia. I think will -- again guidance hasn't changed so we think over the course of the year, the the anticipated orders that we're expecting for Asia will come in.

Patrick Donnelly -- Goldman Sachs -- Analyst

Thank you.

Ronald Hutton -- Vice President and Treasurer

Thank you.

Operator

Thank you (Operator Instructions). Our next question comes from Jack Meehan with Barclays. Your line is now open.

Jack Meehan -- Barclays -- Analyst

Thank you. Good afternoon. I was hoping you could start in the diagnostics business. I was curious how the quality controls business performed in the quarter, just given that usually pretty steady-eddy, I'm surprised it wasn't called out for growth, were there any one-time factors in the quarter or geographic point you would highlight?

John Hertia -- Executive Vice President, President

This is John Heritia. It did grow a little bit in the quarter but but not a call out business, a part of that mitigated growth was related to the earlier comments that we had and ordering patterns in China and in certain parts of Europe.

Jack Meehan -- Barclays -- Analyst

Got it. And then, I was curious on the Droplet Digital side, how some of the liquid biopsy rollout, how that's going and similarly any updates on timing of rollout of applications in single cell?

Annette Tumolo -- Executive Vice President, President, Life Science Group

Sure. So you may have heard that we achieved FDA clearance of the first Droplet Digital platform and test for use in liquid biopsy to monitor molecular response to chronic lukemia and we are going to launch that product in the second quarter by the end of the second quarter. So that was a really big development for us and we expect to see that help expand the adoption of lab developed tests on that platform, so these are all things that are helping expand our share in the liquid biopsy market.

On the NGS sample prep single cell front, we have announced that we are launching in the next few weeks, a new application for interrogating the epigenomics of single cell, it's an attack seek kit for single cell NGS sample prep. So that's our next application coming out.

Jack Meehan -- Barclays -- Analyst

Great and just one final question, could you give a little bit more color on the sizing and the nature of the acquisition on the Life Science side in the quarter and any thoughts around the attractiveness of buyback at this point?

Annette Tumolo -- Executive Vice President, President, Life Science Group

I can answer the first part. We acquired a novel technology for genomic reagent application and right now we're kind of heads down, focused on getting the product transferred into our manufacturing plants, we plan to launch probably in the 4th quarter of this year and we'll have more to say about it closer to launch.

Ronald Hutton -- Vice President and Treasurer

And Jack to your second question. So in Q1, I mean after we filed, we had a close window, so we were not able to since the beginning of the year to be in the market. Generally speaking we will continue to be opportunistic with the buyback and it depends on the timing and when we feel that it sees the right opportunity for us to step in.

Jack Meehan -- Barclays -- Analyst

Okay, that makes sense. Thank you Ron.

Ronald Hutton -- Vice President and Treasurer

Thank you.

Operator

Thank you and I am showing no further questions in the queue at this time, I'd like to turn the call back to your Ilan Daskal for any closing remarks.

Ilan Daskal -- Executive Vice President, Chief Financial Officer

Do you want to pull one more time may be?

Operator

Certainly. (Operator Instructions) we'll take a moment to see if any final questions up here in the queue. We do have a follow-up from Jack Meehan with Barclays . Your line is now open.

Jack Meehan -- Barclays -- Analyst

I'll continue with a couple others that I had, I guess you called out some of the one-timers in the first quarter. Is there anything just as we think about the progression into the second quarter and into the second half. You would know, just in terms of one-timers year-over-year?

Norman Schwartz -- Chairman of the Board, President and Chief Executive Officer

So, one timers for example on the top-line on the process from, it's going to fluctuate as it does every year and that's the one that I can think about here right now.

Jack Meehan -- Barclays -- Analyst

Okay. And then the other progression I wanted to ask was on the gross margin side, I know there's been a little bit of movement related to the blood typing instrument versus reagent pieces but just as we think about the progression through the rest of the year, anything on that you would point out to you?

Norman Schwartz -- Chairman of the Board, President and Chief Executive Officer

In blood typing specifically?

Jack Meehan -- Barclays -- Analyst

Or just overall, which would impact the gross margins for the business.

Norman Schwartz -- Chairman of the Board, President and Chief Executive Officer

So generally, we don't break down the specific of each product line but the growth between blood typing is very nice and the pull through continues to be healthy and we are very pleased with the progress, I mean including the penetration into the U.S. market.

Jack Meehan -- Barclays -- Analyst

Okay. Do you still think 55.5 to 56 is a good range for the full year?

Norman Schwartz -- Chairman of the Board, President and Chief Executive Officer

Yes, we do.

Jack Meehan -- Barclays -- Analyst

Okay, thank you guys.

Norman Schwartz -- Chairman of the Board, President and Chief Executive Officer

Thank you.

Operator

We have a question from Kristine Singles, a Private Investor. Your line is now open.

Kristine Singles -- Private Investor -- Analyst

Thank you. Hello everyone. I just wanted to take a minute to say farewell and certainly thank the investment community for your interest and support over these many years. I've certainly enjoyed working with you very much. And I also wanted to say that I'm confident that Bio-Rad is in good hands and well positioned for the future and like you, we all be like you, I'll be excited to what the future unfolds. So with that, I'll say goodbye and best wishes for continued success and hopefully our paths will cross again one day.

Ronald Hutton -- Vice President and Treasurer

Thank you, Christine. I wanted to thank you also for your support in my transition here in the past few weeks. I don't know, Norman if you want to add anything?

Norman Schwartz -- Chairman of the Board, President and Chief Executive Officer

No.

Ronald Hutton -- Vice President and Treasurer

No, OK good. Thank you Christine.

Kristine Singles -- Private Investor -- Analyst

Okay, thank you.

Norman Schwartz -- Chairman of the Board, President and Chief Executive Officer

Thanks.

Operator

Thank you.(Operator Instructions), I am showing no questions in the queue at this time.

Ronald Hutton -- Vice President and Treasurer

Okay, thank you everyone for joining our call today and we appreciate your continued interest. Thank you.

Operator

Ladies and gentlemen, thank you for your participation in today's program. This does concluded and you may all disconnect. Everyone have a great day.

Duration: 36 minutes

Call participants:

Ronald Hutton -- Vice President and Treasurer

Ilan Daskal -- Executive Vice President, Chief Financial Officer

Norman Schwartz -- Chairman of the Board, President and Chief Executive Officer

Annette Tumolo -- Executive Vice President, President, Life Science Group

Andrew Last -- Executive Vice President, Chief Operating Officer

John Hertia -- Executive Vice President, President

Michael Sarcone -- Deutsche Bank -- Analyst

Brandon Couillard -- Jefferies -- Analyst

Patrick Donnelly -- Goldman Sachs -- Analyst

Jack Meehan -- Barclays -- Analyst

Kristine Singles -- Private Investor -- Analyst

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