CORRECTED-WRAPUP 12-Israel fighting with Gaza, Lebanon intensifies; US bolsters Middle East weaponry

(Corrects death toll and number of wounded in paragraph 16)

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LATEST DEVELOPMENTS:

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Biden holds call with Netanyahu

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Biden and Pope Francis discuss 'need to prevent escalation'

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France's Macron and Dutch Prime Minister Rutte to visit Israel this week

By Nidal al-Mughrabi and Dan Williams

GAZA/JERUSALEM, Oct 22 (Reuters) - Fears that the Israel-Hamas war could mushroom into a wider Middle East conflict rose on Sunday with Washington warning of a significant risk to U.S. interests in the region as ally Israel pounded Gaza and clashes on its border with Lebanon intensified.

Gaza's Health Ministry said 266 Palestinians, including 117 children, had been killed by Israeli air strikes in the past 24 hours in the enclave, to which Israel laid "total siege" after a deadly mass infiltration into Israel by Hamas gunmen on Oct. 7.

In neighbouring Syria, where Hamas' main regional backer Iran has a military presence, Israeli missiles hit Damascus and Aleppo international airports early on Sunday, putting both out of service and killing two workers, Syrian state media said.

Along Israel's northern border with Lebanon, the Iran-backed Hezbollah group has clashed with Israeli forces in support of Hamas in the deadliest escalation of frontier violence since an Israel-Hezbollah war in 2006.

With violence around its heavily guarded borders increasing, Israel on Sunday added 14 communities close to Lebanon and Syria to its evacuation contingency plan in the north of the country.

Palestinian Prime Minister Mohammad Shtayyeh called on the international community to create "a united front" to stop Israel's attacks against Gaza and allow in desperately needed aid which has only begun to trickle in.

U.S. Defense Secretary Lloyd Austin said on Saturday that Washington would send more military assets to the Middle East in support of Israel and strengthen the U.S. defence posture in the region after "recent escalations by Iran and its proxy forces" - a reference to Hezbollah, Palestinian and other militants.

Austin told ABC's "This Week" program on Sunday: "We're concerned about potential escalation. In fact, what we're seeing ... is the prospect of a significant escalation of attacks on our troops and our people throughout the region.

"If any group or any country is looking to widen this conflict and take advantage of this very unfortunate situation ... our advice is: don’t," he added.

U.S. President Joe Biden on Sunday held a call with Israeli Prime Minister Benjamin Netanyahu to discuss the conflict, the White House said. Biden also spoke with Pope Francis, discussing "the need to prevent escalation in the region and to work toward a durable peace in the Middle East", the White House said.