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We're Keeping An Eye On Spero Therapeutics' (NASDAQ:SPRO) Cash Burn Rate

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Just because a business does not make any money, does not mean that the stock will go down. For example, biotech and mining exploration companies often lose money for years before finding success with a new treatment or mineral discovery. Nonetheless, only a fool would ignore the risk that a loss making company burns through its cash too quickly.

So, the natural question for Spero Therapeutics (NASDAQ:SPRO) shareholders is whether they should be concerned by its rate of cash burn. For the purposes of this article, cash burn is the annual rate at which an unprofitable company spends cash to fund its growth; its negative free cash flow. Let's start with an examination of the business' cash, relative to its cash burn.

How Long Is Spero Therapeutics' Cash Runway?

You can calculate a company's cash runway by dividing the amount of cash it has by the rate at which it is spending that cash. As at December 2024, Spero Therapeutics had cash of US$53m and no debt. In the last year, its cash burn was US$23m. That means it had a cash runway of about 2.3 years as of December 2024. Arguably, that's a prudent and sensible length of runway to have. The image below shows how its cash balance has been changing over the last few years.

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NasdaqGS:SPRO Debt to Equity History March 29th 2025

Check out our latest analysis for Spero Therapeutics

How Well Is Spero Therapeutics Growing?

It was fairly positive to see that Spero Therapeutics reduced its cash burn by 29% during the last year. But it makes us pessimistic to see that operating revenue slid 54% in that time. Taken together, we think these growth metrics are a little worrying. While the past is always worth studying, it is the future that matters most of all. So you might want to take a peek at how much the company is expected to grow in the next few years.

Can Spero Therapeutics Raise More Cash Easily?

While Spero Therapeutics seems to be in a fairly good position, it's still worth considering how easily it could raise more cash, even just to fuel faster growth. Issuing new shares, or taking on debt, are the most common ways for a listed company to raise more money for its business. One of the main advantages held by publicly listed companies is that they can sell shares to investors to raise cash and fund growth. We can compare a company's cash burn to its market capitalisation to get a sense for how many new shares a company would have to issue to fund one year's operations.

Since it has a market capitalisation of US$42m, Spero Therapeutics' US$23m in cash burn equates to about 56% of its market value. From this perspective, it seems that the company spent a huge amount relative to its market value, and we'd be very wary of a painful capital raising.