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Wedbush initiated coverage of Rocket Pharmaceuticals (RCKT) with an Outperform rating and $32 price target The analyst believes 2025 “should be an inflection year” for Rocket with multiple clinical and regulatory catalysts “potentially creating strong momentum” with the shares trading near 52-week lows. Rocket’s RP-A501 for Danon disease has potential to be a $1B commercial opportunity, the analyst tells investors in a research note. The firm thinks an accelerated approval pathway may be possible for RP-A601 in arrhythmogenic cardiomyopathy caused by mutations in the PKP2 gene, saying preclinical data from a mouse model show “robust” protein expression, reversal of phenotypes, and near complete rescue of early mortality. Wedbush expects the initial Phase 1 data in the first half of 2025 to show protein expression in cardiomyocytes, which could potentially lead to positive cardiac functional changes that can be detected by lab measures.
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