Nu.Q® Discover tools provide drug developers and scientists with a range of rapid epigenetic profiling assays across pre-clinical and clinical development pathways from discovery to market ready
HENDERSON, Nev., March 4, 2025 /PRNewswire/ -- VolitionRx Limited (NYSE AMERICAN: VNRX) ("Volition"), a multi-national epigenetics company, today announces that it has signed an agreement with a leading pharmaceutical company to utilize Volition's Nu.Q® Discover biomarkers in a longitudinal Phase 1/2b study. The Nu.Q® Discover program provides drug developers and scientists with a range of state-of-the-art assays for rapid epigenetic profiling in disease model development, preclinical testing, and clinical studies from discovery to market ready.
Following a successful pilot study, two of Volition's Nu.Q® Discover assays were selected for use in this study. It is expected to be completed over a 12-18 month period, generating significant revenue for Volition for this study alone, with further projects being discussed.
Dr. Andrew Retter, Chief Medical Officer at Volition, said:
"This is a significant milestone for our Nu.Q® Discover program: the first human clinical study with a pharmaceutical company sponsor, utilizing Volition's biomarkers to measure disease progression and response to treatment in a longitudinal phase 1/2b trial of an experimental drug.
We are delighted to support the pharmaceutical company's clinical efforts in developing new drugs for the treatment of a large, unmet medical need. The inclusion of our nucleosome-based biomarkers in this clinical trial demonstrates the growing recognition of their value in clinical development.
We are in further discussions with this and other companies, and anticipate additional clinical studies, which we believe will further validate the capabilities of our technology and strengthen our position in the pharmaco-epigenetics market."
About Nucleosome Expertise for Clinical Trial Enrichment
This collaboration represents an exciting opportunity for Volition to leverage its extensive experience with nucleosomes and scientific expertise in epigenetics to enhance research. By incorporating Nu.Q® Discover biomarkers into the sponsor's study design, Volition is enabling an enrichment strategy that can help identify patients most likely to respond to treatment or experience disease progression.
Clinical trial enrichment is the prospective use of patient characteristics to select a study population with a higher likelihood of demonstrating a treatment effect. This aligns perfectly with Volition's technological capabilities. The company's nucleosome quantification technology provides valuable biological insights that can be used to stratify patients, potentially increasing trial efficiency and improving the signal-to-noise ratio in treatment response assessment.
This approach represents a significant step toward Volition's long-term goal of enabling precision therapy for patients. By identifying specific epigenetic signatures associated with disease states and treatment responses, Volition aims to help clinicians match patients with the therapies most likely to benefit them, while sparing them from treatments unlikely to be effective.
The application of Nu.Q® Discover in this Phase 1b/2 trial demonstrates how Volition's nucleosome expertise is transitioning from research to clinical applications, creating value for pharmaceutical partners while advancing the field of personalized medicine. As this and future studies generate additional data about nucleosome based biomarkers' predictive and prognostic capabilities, Volition is well-positioned to expand its role in precision medicine and targeted therapeutic approaches.
About Nu.Q® Discover
Volition's Nu.Q® Discover program enables drug developers and scientists access to a range of state-of-the-art assays for rapid epigenetic profiling in disease model development, preclinical testing, and clinical studies from discovery to market ready.
Nu.Q® Discover is built on proprietary nucleosome quantification technology. It is a valuable research tool for R&D professionals working within the field of pharmaco-epigenetics, studying the epigenetic basis for variation in response to drugs.
About Volition
Volition is a multi-national epigenetics company focused on advancing the science of epigenetics. Volition is dedicated to saving lives and improving outcomes for people and animals with life-altering diseases through earlier detection, as well as disease and treatment monitoring.
Through its subsidiaries, Volition is developing and commercializing simple, easy to use, cost-effective blood tests to help diagnose and monitor a range of diseases, including some cancers and diseases associated with NETosis, such as sepsis. Early diagnosis and monitoring have the potential not only to prolong the life of patients but also improve their quality of life.
Volition's research and development activities are centered in Belgium, with an innovation laboratory and office in the U.S. and London.
The contents found at Volition's website address are not incorporated by reference into this document and should not be considered part of this document. Such website address is included in this document as an inactive textual reference only.
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Nucleosomics™, Capture-PCR™ and Nu.Q® and their respective logos are trademarks and/or service marks of VolitionRx Limited and its subsidiaries. All other trademarks, service marks and trade names referred to in this press release are the property of their respective owners.
