Expanding commercial offering as a bio-partnering model, currently in active discussions with pharmaceutical companies
HENDERSON, Nev., Feb. 6, 2025 /PRNewswire/ -- VolitionRx Limited (NYSE AMERICAN: VNRX) Volition a multi-national epigenetics company, announces its first commercial sale of Volition's High Throughput Synthetic Sepsis method that measures Neutrophil Extracellular Traps "NETs" activation and inhibition in whole blood in real time, helping companies develop new therapeutics to combat sepsis and other NETs-related disease.
Dr. Jasmine Kway, CEO of Singapore Volition and Commercial Lead for Nu.Q® Discover said:
"Our High Throughput NETs model represents a critical breakthrough in understanding neutrophil biology; A fundamental understanding of NETs-related diseases in vivo has been challenging to date."
"Most studies rely on isolated primary neutrophils, which miss many potential crosstalk events which happen in whole blood. By enabling more precise measurement of NETs formation, we're opening new pathways for therapeutic interventions in NETs-related diseases."
Key Highlights of Rapid High-Throughput Model
- Method to quantitatively monitor NETs release in real time - Eliminates neutrophil isolation steps that can alter cellular responses - Builds on foundational research published in the Journal of Thrombosis and Hemostasis - Provides a more physiologically relevant environment for studying neutrophil responses
Dr. Terry Kelly, Chief Innovation Officer at Volition America, added:
"This marks the culmination of the last two years of work demonstrating the ability to induce and inhibit NETs formation in healthy blood using an automated high throughput system. There is an increasing trend of published scientific literature about NETs as scientists and biopharmaceutical companies race to develop new interventions based on an improved understanding of the underlying biology and mechanisms at play."
Volition's innovative approach addresses a significant technical limitation in previous research. By measuring NETs directly in whole blood, the method avoids potential alterations in neutrophil responses caused by isolation procedures, as highlighted by recent commentary in JTH.
"This technology has the potential to unlock new understanding of conditions characterized by uncontrolled NETs formation and can serve as a key tool in translational research and the study of NETosis related disease."
Sepsis, NETs and NETosis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection It is responsible for ~370,000 US deaths annually. Neutrophils are an integral part of the innate immune response and rapidly clear pathogens from circulation using neutrophil extracellular traps (NETs) released through a process called NETosis.
NETs have become more relevant in disease but have not been widely characterized in humans. NETs are essential for trapping and neutralizing pathogens, but overproduction or uncontrolled formation (NETosis) can lead to tissue damage and disease progression during the inflammatory response.
Studies in NETosis have been mostly limited to isolated systems with unnatural stimulation. However, understanding natural NETosis activation and the underlying mechanisms could lead to new biomarkers and understanding of how these neutrophil associated diseases are regulated in vivo.
Volition is developing simple, easy-to-use, cost-effective blood tests to help diagnose and monitor a range of life-altering diseases in both humans and animals.
For more information about Volition's technology go to: www.volition.com
About Volition Volition is a multi-national company focused on advancing the science of epigenetics. Volition is dedicated to saving lives and improving outcomes for people and animals with life-altering diseases through earlier detection, as well as disease and treatment monitoring.
Through its subsidiaries, Volition is developing and commercializing simple, easy to use, cost-effective blood tests to help diagnose and monitor a range of diseases, including some cancers and diseases associated with NETosis, such as sepsis. Early diagnosis and monitoring have the potential not only to prolong the life of patients but also improve their quality of life.
Volition's research and development activities are centered in Belgium, with an innovation laboratory and office in the U.S. and additional offices in London and Singapore.
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