VIFOR PHARMA GROUP INCREASES EQUITY INVESTMENT IN CHEMOCENTRYX
  • Vifor Pharma Group increases equity stake in ChemoCentryx from 6.6% to 21.2%.

  • Vifor Pharma Group acquires an additional 7,343,492 common shares of ChemoCentryx, Inc. (CCXI) from GlaxoSmithKline - an additional 14.6% stake in the company.

  • As a result Vifor Pharma Group will hold a total of 21.2% of ChemoCentryx on completion of the transaction.

The increased investment follows the establishment of a partnership with ChemoCentryx, which began in May 2016. Under the terms of the current in-licensing agreements, Vifor Pharma Group has the exclusive rights to commercialize avacopan and CCX140 for orphan and rare renal diseases in all markets outside of the United States.

"This investment is a logical step in strengthening our partnership with ChemoCentryx and towards realizing our vision of becoming global leader in nephrology," said Stefan Schulze, Vifor Pharma Group President of the Executive Committee and COO. "It further demonstrates our belief in the significant potential of these products to provide important new treatments to patients with debilitating kidney diseases. As a major shareholder we believe we can support ChemoCentryx in exploring the strength of its pipeline and the technology platform."

"Vifor Pharma has shown itself to be an excellent partner, committed with us at ChemoCentryx to changing the treatment landscape for people with serious kidney disease", said Thomas J. Schall, Ph.D., President and CEO of ChemoCentryx. "We continue to be impressed with Vifor Pharma`s expert preparations to market avacopan and CCX140 in their territories, while we at ChemoCentryx focus on the U.S. We`re delighted with this excellent ongoing alliance."

The transaction is subject to certain closing conditions, including expiration or termination of the applicable waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended. The parties expect to complete the transaction in Q4 2018.

FURTHER INFORMATION

Vifor Pharma Contacts

Media Relations
Heide Hauer
Head of Corporate Communications
Tel.: +41 58 851 80 87
E-mail: media@viforpharma.com

Investor Relations
Julien Vignot
Head of Investor Relations
Tel.: +41 58 851 66 90
E-mail: investors@viforpharma.com

ChemoCentryx Contacts

Media
Stephanie Tomei
Tel.: +1 408-234-1279
E-mail: media@chemocentryx.com

Investors
Steve Klass at Burns McClellan
Tel.: +1 212-213-0006
E-mail: sklass@burnsmc.com

Avacopan is currently in late-stage clinical development for the treatment of rare diseases, including rare inflammatory renal diseases. Avacopan is a first in class, oral, highly selective inhibitor of the complement C5a receptor (C5aR) which is central to the underlying pathophysiology of Anti-neutrophil cytoplasmic antibody associated vasculitis (AAV), a group of rare, serious autoimmune diseases which lead to significant morbidity and mortality. In a randomized, double-blind, placebo controlled Phase II clinical study in AAV patients, the CLEAR trial, avacopan demonstrated a favourable risk/benefit profile and therapeutic efficacy to control active vasculitis rapidly. By blocking the terminal effector complement protein C5a, avacopan can selectively inhibit the AAV inflammatory cycle involving the complement system and neutrophils while preserving the function of the C5b-9 membrane attack complex which is important in the immune response to encapsulated bacterial infection.