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Two In Vitro Studies on Eravacycline (XERAVA®) Presented at IDWeek, Demonstrating Its Sustained and Robust Antimicrobial Activity

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SHANGHAI, Nov. 22, 2024 /PRNewswire/ -- Everest Medicines (HKEX 1952.HK, "Everest", or the "Company"), a biopharmaceutical company focused on the discovery, clinical development, manufacturing, and commercialization of innovative therapeutics, today announced that data on its critical-care, anti-infective product, eravacycline (XERAVA®), was recently presented in Los Angeles, California at IDWeek 2024. Among the findings, two in vitro study results further demonstrated the broad and consistent antimicrobial activity of eravacycline.

The first study evaluated the in vitro antimicrobial activity of eravacycline against Carbapenem-resistant Acinetobacter baumannii (CRAB), using broth microdilution, MIC test strip (MTS), and disk diffusion methods to evaluate the susceptibility of eravacycline against 587 strains of CRAB. Using the recently approved, ChinaCAST breakpoint of 1 µg/mL the results showed a high susceptibility rate of eravacycline against CRAB, with a susceptibility rate of 98.13% (576/587) detected by broth microdilution, 97.96% (575/587) and 97.61% (573/587) susceptibility rates detected by MTS and disk diffusion methods, respectively. The results of the three antimicrobial susceptibility test (AST) methods were consistent. The study results demonstrated the high percent susceptibility of eravacycline to CRAB in vitro, and the consistency across the three AST methods underscored the reliability and stability of eravacycline's susceptibility results in clinical microbiology settings. Xerava® is not indicated for infections caused by Acinetobacter spp. including CRAB. Additional clinical data are necessary to establish efficacy.

The second study evaluated the in vitro activity of eravacycline against 23,127 global clinical isolates of major Gram-positive and Gram-negative bacteria, including drug-resistant strains collected from various regions such as Asia, Europe, and North America from 2018 to 2022. The results showed that since its approval in 2018, eravacycline has consistently maintained a high level of susceptibility against clinically relevant pathogens across diverse geographic regions and infection sites. This stable in vitro antimicrobial activity over the past five years supports eravacycline's use in treating complicated intra-abdominal infections caused by both Gram-negative and Gram-positive bacteria.

"The in vitro study results for eravacycline presented at IDWeek further underscore its broad-spectrum antibacterial coverage and potent activity as the world's first and only new class of antibacterial—fluorocyclines. This reinforces its clinical potential in treating infections caused by multidrug-resistant pathogens," said Rogers Yongqing Luo, Chief Executive Officer of Everest Medicines. "With the global threat of antimicrobial resistance on the rise, the latest findings on eravacycline are encouraging. We are committed to collaborating with medical experts across specialties to further explore and promote its rational use, ensuring that eravacycline can effectively support more patients affected by complex infections."


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