The reason Uber is investing in this hot market
The reason Uber is investing in this hot market · CNBC

CAIRO — In 2012, veteran venture capitalist Ahmed El Alfi first noticed that the former campus of the American University in Cairo was abandoned, occupied only by a colony of wildcats. But the five buildings, with their colonnades and a long, leafy courtyard, brought to mind a mosque or church, and he could see the potential.

"It was a place that you could immediately envision people interacting in a positive way," he recalled. "It's inward facing, where we could be isolated from the outside and implement a positive vision."

Alfi has invested millions to turn the campus, just a few blocks from famous Tahrir Square, into a technology hub. Open for two years, the GrEEK Campus has now become the center of a tech ecosystem that, against the odds and geopolitical obstacles, is breaking out in Egypt .

Home to 112 companies, it's already producing success stories: start-ups that are landing funding rounds and have a good chance of acquisition in the next few years by global companies wanting an entrance into Egypt's big market, one of the keys to the Middle East and Africa. On Dec. 12 the campus will host several thousand for a big emerging markets tech summit called RiseUp.

The burgeoning success isn't a surprise to those who know Alfi's U.S. track record. Egyptian-born Alfi, who was reared mostly in the United States, had a stellar career in southern California that took him from Wall Street to venture investing to the successful sale of his family's medical business. He spent 10 years at Jeffries, became an independent venture capitalist in 1990, backed PC Mall before its IPO in 1995 and then sold his family's company, Alfigen, to Genzyme in 2004.

Looking for a new challenge, he moved to Egypt in 2006. He found a nascent community of young entrepreneurs who were "doing many things wrong." Helping them became his next project.

He rarely seeks the spotlight, but "he returned to Egypt at a time when almost no one over 40 anywhere in the world thought an ecosystem was possible there," said Christopher Schroeder, a U.S. venture investor and author who sits on the advisory board of the business school of the American University in Cairo, in an email to CNBC. "He built strategically, step by step — investment, mentorship, bizdev relations, academic relations, outreach to U.S. and global ecosystems ... And he put his money, time and reputation to it, all-in."

Read MoreThe top global hot spots for entrepreneurs in 2015

Companies at the campus include Yaoota, a Shopzilla-style shopping engine, which recently landed a $2.7 million A round from UAE-based KBBO. SuperMama, a content site for parents, has graduated from the campus into its own office and has a total of 5.3 million visitors monthly. Another Egyptian start-up, BasharSoft, landed a $1.7 million round for its recruiting website, Wuzzuf, from Sweden-based Vostok New Ventures and U.K.-based Piton Capital.