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Robert Spignesi

Thank you, Mike. Good morning, everyone, and thank you for joining us. I will begin my prepared remarks with a brief overview of our fourth quarter 2024 performance and highlights as announced in our press release this morning.
I will then discuss the global distribution and collaboration agreement we announced last night before turning the call over to Sean, who will provide a more detailed review of our financial results in our 2025 outlook. Total revenue was $8.2 million in the fourth quarter, representing 30% year over year growth and a quarterly record.
Recurring revenue was $4.2 million representing growth of 27% compared to the prior year quarter. We play six growth direct systems in Q4, bringing our total to 21 system placements for the full year.
On a cumulative basis through the end of 2024, we have now placed 162 Growth Direct systems globally.
Including 137 fully-validated systems. Fourth quarter gross margins improved to 12%, up sequentially from 8% in the third quarter, and a 15% point improvement compared to the prior year quarter.
This reflects continued progress in improving our cost structure and enhanced operating leverage in the business. The strong fourth quarter performance marks our ninth consecutive quarter of meeting or exceeding our revenue guidance and positions us well for 2025.
Now I'll turn to last night's press release announcing our global distribution and collaboration agreement with the life science business of Merck KGaA, Darmstadt, Germany, which operates in the US as Millipore Sigma.
To begin, I will provide some context around our decision to enter into this agreement and why we believe Millipore Sigma is an excellent strategic partner for Rapid Micro Biosystems. As a long standing global leader in life sciences, Millipore Sigma shares a common customer base in the pharmaceutical segment with rapid microbiome.
Offering a comprehensive and complementary product portfolio, supported by an extensive commercial organization with deep relationships and experience selling into pharmaceutical quality control and manufacturing.
Moreover, Millipore Sigma also serves adjacent segments such as personal care and medical devices, among others. This aligns strongly with our top priority of accelerating Growth Direct system placements.
Additionally, as a global supplier to the life sciences industry, this partnership with Millipore Sigma presents opportunities to bring efficiencies to our supply chain to reduce product costs and accelerate our goal of improving gross margins.
Finally, this partnership creates opportunities to drive innovation and develop new technologies and products. So without this context for this partnership, let me now provide more details of the agreement. Millipore Sigma has global co-exclusive rights to sell the Growth Direct system and related consumables.
Their extensive global commercial network, which reaches beyond traditional pharma and biologics manufacturing into key adjacent markets such as personal care, medical devices, cosmetics, and food and beverage, aligns well with Rapid Micro's long-term growth objectives.
By leveraging Millipore Sigma scale and expertise, we expect they will significantly expand Growth Direct's reach, enhance accessibility with existing customers, and attract new customers. Additionally, access to these adjacent markets will substantially increase Growth Direct's total addressable market.
For the first two years of this five-year agreement, Millipore Sigma has committed to purchasing a minimum number of growth systems.
This commitment is heavily weighted towards the second year, and we expect it to have a meaningful impact in 2026. At the same time and throughout the full term of the agreement, Rapid Micro will continue to utilize its existing global direct sales team and distribution channels to sell and place Growth Direct systems. Importantly, we will also continue to validate and service all Growth Direct systems to include the systems Millipore Sigma cells.
A key component of this agreement is a joint commitment between Rapid Micro and Millipore Sigma to identify opportunities to bring efficiencies to our supply chain to accelerate our goal of gross marginal improvement.
Initial focus areas for this collaboration may include cultural media, plastic consumables, sterilization, logistics and warehousing, as well as packaging. We are confident that this collaborative approach will build upon our recent progress and deliver incremental and sustainable improvements in gross margin.
And lastly, the agreement enables opportunities for collaboration on joint development of new products, enhancement of existing products, and expansion of service offerings to benefit customer workflows and create additional revenue and marginal opportunities.
We held a multi-day planning and kickoff meeting with our Millepore Sigma colleagues this week, and we could not be more excited to partner with such a recognized and highly respected leader in the life sciences industry.
This agreement combines Rapid Micro's market-leading Growth Direct technology platform with Millipore Sigma's global scale, brand strength, and industry leadership. We are confident this collaboration will enhance value to customers worldwide while meaningfully advancing our priorities of accelerating Growth Direct system placements.
Improving gross margins and driving innovation. Before turning the call over to Sean, I'd like to share my perspective on our outlook for 2025.
Our priorities this year remain consistent with 2024. Our top priority remains accelerating Growth Direct system placements. Second, we remain focused on improving gross margins.
Third, we are committed to developing and commercializing innovative new products. Lastly, we will continue to prudently manage our cash and maintain a strong balance sheet.
Our successful collaboration with Lanza Which resulted in end to end automation of their environmental monitoring QC process using the Growth Direct platform across our global [71G] manufacturing network reinforces our confidence that we are the industry standard. And provides a clear blueprint for the industry to emulate.
We have multiple customers in our sales funnel with plans for similar global multi-system rollouts.
This also includes a growing sales funnel for Rapid Sterility, which is being driven by its value proposition for full automation and faster times results for this critical end of line test.
In 2025, we expect to improve gross margins by building upon our second half, 2024 inflection and continuing our programs to reduce product costs, enhance manufacturing efficiencies, and improve service productivity. We expect further gains in operating leverage as we move forward and we will remain disciplined with task management.
While we believe there is potential for Miller for Sigma to contribute to revenue in 2025, we are not assuming any contribution in our outlook. However, we expect this partnership to have a transformative impact on the business, to include our system placement and marginal improvement priorities.
Providing meaningful benefits in 2026 and beyond. With this in mind, we believe our outlook is both prudent and achievable, and look forward to updating you as the year progresses.
In closing, we believe the strength of our underlying business, the significant advantages of our partnership with Millipore Sigma. And our continued focus on delivering value to customers positioned us to drive sustained shareholder value creation in 2025 and beyond. And with that, I will now turn the call over to Sean to discuss our fourth quarter performance and outlook in more detail. Sean.

Sean Wirtjes

Thanks, Rob, and good morning everyone.
I'll begin my comments this morning with a review of our fourth quarter 2024 results and then discuss our first quarter and full year outlook for 2025. We will then open the call up for questions.
Fourth quarter revenue increased 30% to a record $8.2 million compared to $6.3 million in Q4 2023. During the fourth quarter, we placed six Growth Direct systems, which was consistent with the fourth quarter last year. We also completed four validations in the quarter compared to nine in Q4 last year.
Product revenue, which is comprised of systems and consumables, increased 27% to $5.2 million in the fourth quarter compared to $4.1 million in Q4 2023. Consumable revenue grew by over 30% in the fourth quarter compared to Q4 last year.
Service revenue increased 35% to $3 million in the fourth quarter compared to $2.2 million in Q4 2023. This was driven by double digit revenue growth across validation services, field service, and service contracts.
Fourth quarter recurring revenue, which consists of consumables and service contracts, increased 27% to $4.2 million. Non-recurring revenue, which is comprised mainly of systems and validation revenue, increased 32% to $4 million.
Turning to gross margins, product margins were 8% in the fourth quarter compared to 14% in Q4 2023. The improvement was largely due to continued progress on product cost reduction initiatives and increased manufacturing efficiencies in our consumables business.
Service margins were a record $1.4 million or 47% in the fourth quarter compared to $0.4 million or 19% in Q4 last year. The 28% point improvement was driven by higher revenue and productivity, as well as lower headcount and other service related costs.
On a combined basis, fourth quarter gross margins were a record $1 million or 12% compared to negative $0.2 million or 3% in Q4 last year. Of note, full year 2024 gross margins were effectively break even compared to negative 24% for the full-year 2023. We are pleased with the significant progress we've made on margins over the course of the past two years and remain laser focused on driving substantial incremental improvement moving forward.
Moving down the P&L, total operating expenses were $11.2 million in the fourth quarter, representing a decrease of 7% from $12 million in Q4 2023, largely due to benefits from the operational efficiency program we announced in August 2024.
Within OpEx, R&D expenses were $3.4 million representing an increase of 3%, which was mainly associated with new product development activities. Sales and marketing expenses were $3 million representing a decrease of 6%. And SG&A expenses were $4.8 million representing a decrease of 13% due mainly to lower headcount related costs.
Net loss was $9.7 million in Q4. This compares to a net loss of $11.2 million in Q4 last year. Net loss per share was $0.22 in Q4 compared to net loss per share of $0.26 in the prior year quarter.
With respect to non-cash expenses and capital expenditures, depreciation and amortization expenses were $0.9 million stock compensation expense was $0.7 million and capital expenditures were $0.1 million in the fourth quarter. We ended the year with approximately $51 million in cash and investments.
Now I'll turn to our 2025 outlook. While we believe there is potential for Millipore Sigma to contribute to system placements and revenue in 2025, our initial guidance does not assume any such contribution. We believe this is prudent given our typical sales cycle.
Conversely, our guidance does account for some ongoing uncertainty around the timing and scale of customer purchase decisions, particularly with respect to larger multi-system opportunities which often involve more complex purchasing considerations and processes.
With that as context, we expect full year 2025 total revenue of at least $32 million with between 21 and 25 system placements. We expect Q1 revenue of at least $6.5 million including at least three system placements, with the sequential decline from Q4 consistent with typical seasonality. We then expect revenue and placements in Q2 and Q3 to be higher than Q1 and then peak in Q4.
Looking at consumables, we expect Q1 revenue to step down slightly from Q4. We then expect consumables revenue to be higher than Q1 in the remaining quarters with variability driven by the timing of customer orders and shipments.
With respect to service, we expect revenue to be between $2.6 million and $3 million in Q1, which is likely to be our highest service revenue quarter in the year, primarily due to the timing of validation activities.
We expect to complete at least 18 validations in 2025, with at least five in the first quarter. Turning to margins, we expect Q1 gross margins to be slightly positive but lower than Q4 due to the revenue seasonality impact I mentioned earlier.
Thereafter, based on our revenue outlook, we expect to maintain positive gross margins in each succeeding quarter of 2025, with variability driven by progress on our product cost reduction and service productivity initiatives, overall revenue volumes, and the revenue mix between systems, consumables, and service in each period.
For the full-year 2025, we expect gross margin as a percentage of revenue to be in the range of high single digits to low 10%s. We expect operating expenses to be between $44 million and $0.48 million dollars for the full year, which reflects the full effect of savings from the operational efficiency program we announced in August 2024.
We expect depreciation and amortization expense of $3 million stock compensation expense of $4 million CapEx of $2 million and other income, which is comprised primarily of interest income of $2 million.
Finally, we expect to burn roughly $30 million in cash for the full year 2025, which would be a roughly $14 million dollar reduction compared to our cash burn in 2024.
Looking further ahead, our strategic priorities of accelerating system placements, improving gross margins, innovating new products, and prudently managing our cash remain unchanged.
Building on our momentum, we believe that our distribution and collaboration agreement with Millipore Sigma has the potential to further accelerate progress on these strategic priorities over the coming years, including a meaningful contribution to system placements beginning in 2026.
That concludes my comments, so at this point we'll open the call up for questions. Operator?

Question and Answer Session

Operator

(Operator Instructions) Dan Arias, Stifel.

Dan Arias

Hey good morning guys, thanks for the questions, Rob, do you think that the Millipore relationship accelerates your entry into new areas that maybe you're not focused on now? I mean, it seems like some of these non-traditional corners of the opportunities that could be open to you sooner if you have those guys helping you out, but I'm not sure whether you see that as the right move strategically when you just think about resources and focus and, hitting the ground running on on some of the things that you're currently doing.

Robert Spignesi

Yeah, Dan, I appreciate the question and the quick answer is yes, I do. So as we've discussed in previous calls, there's adjacent markets such as personal care and cosmetics and med devices that are meaningful in size. But given our focus in pharmaceutical. Manufacturing, we've been focused on in farming, biologics and so, etc. So the Millipore Sigma team is well positioned in those adjacent markets, and that is a, I see a fundamental plank in the strategy behind the relationship.

Dan Arias

Okay.
Okay, and then Seann on the instrument placement outlook for the year, the low end of the guide is actually no better than what you did in 2024, and even the midpoint is only two systems higher. Most people think the spending situation in pharma is better than it was last year.
Looks like you have a nice win here with Lanza. You've got Millipore in the picture, at least in the picture if they're not helping in '25, they're at least there. So help me with the the '21 to '25. I mean, obviously, prudence is a good, it's a good idea here, but it seems like they certainly got the components of, something for something more. I just want to make sure I'm not missing, an element here that would be material to the outlook.

Sean Wirtjes

Yeah, sure, Dan. Yeah, so you said one of the key words there, I think prudent and achievable. That's our goal, our philosophy as we kind of come into the new year and set our guidance.
I think in the broader environment, I don't think we are seeing meaningful changes from what we've seen in '24 in terms of how customers are operating around the purchasing process, the bar.
Still tends to be a little higher than it was at certain times in the past, so we're continuing to monitor that monitor that. But I don't think we've seen any meaningful improvement in that at this point. And that's that assumption is baked into this guidance. I, we touched on it in the script. I think very importantly, we are not including anything for Millipore Sigma.
We do think there's an opportunity there, but it's going to take some time to get them up to speed. Obviously our sales cycle can be 12 months plus. So it's factoring that in. That was kind of the rationale for for the approach that we took there. And then I think with, given the environment and what we're seeing and not seeing there, I think, we have a number of large multi-system orders in the funnel and we're not baking those into the guide right now, just given the environment and the time that we expect it will take to bring those resolutions. So to the extent we're able to convert those during the year, that will be upside as well. So that's kind of how we approached it coming into the to the new year in 2025.

Dan Arias

Is there something -- (multiple speakers)

Robert Spignesi

Are you sure?

Dan Arias

Okay. Here I go. Are there some number of systems that you expect to go to Lanza through this collaboration this eyar?

Robert Spignesi

So I'll speak more broadly, this is the point I was I was going to make, so it's an important. It's an important note or feature that that it bears repeating. So our guide for for '25, as Sean mentioned, does not include any contribution from our our new collaboration with Millepore Sigma, nor does it include the more meaningful multi-system orders, that we have in our funnel that we are quite excited about, and there are multiple. And the reason why we have not.
Included though is again consistent with our prudent approaches while exciting they can and they're moving, they can also be tough to put a pin in with regard to timing. These are typically global in nature, multi-site, multi-region, multi-stakeholder, and as you may imagine, they can be a little more complex and a bit more time consuming to have to close and ship.
That's why we haven't included those concluded those, that all being said. We reserve the right for upside here on both the Millipore Sigma relationship in 25, as well as our direct selling against some of these large multi-system orders. And as I mentioned in the remarks, we'll keep everyone updated as the year unfolds.

Dan Arias

Okay appreciate it thank you.

Operator

Paul Knight, KeyBanc.

Paul Knight

Hey Rob, on the Merck and Millipore collaboration, are they going to sell into the biopharma or is it biopharma in a particular region? How do you prevent same people in the same building and then the other is what do you think this does for gross margin with Merck KGaA involved? Do you have a margin pick up goal maybe in even 2026 from them getting involved maybe in supply.

Robert Spignesi

Paul, thanks for thanks for the question. So, the first one, it basically goes to, channel conflict effectively. Yes, they will be selling into not only pharmaceutical, and biologics, but more broadly, segments, personal care, cosmetics, etc. Which we consider a growth adjacency that we're not currently in, with respect to with respect to our core market of pharmaceutical manufacturing, we have been diligently working with the team and are are comfortable with our go to market approach and how we're going to, manage our respective, sales funnels.
With regard to margin, yes. The goal here again, the strategy as I touched on behind the Millipore Sigma relationship is to is to catalyze and accelerate our our core priorities of accelerating system sales, which we touched on, gross margin improvement, which will come through not only volume we anticipate.
But also, as I mentioned, a lot of the components, especially in our consumables notably from a cost of materials standpoint, Millipore Sigma has in their portfolios. There's definitely opportunities there to improve supply chain efficiencies with regard to our factors of input and then of course downstream through logistics and shipping also there's meaningful opportunities. So we would anticipate, and it is part of the core strategy here, that margin. Would feature prominently in our in our relationship.

Sean Wirtjes

Yeah, and Paul, we actually don't procure anything of substance from them today, so we have a relatively clean slate to go after and as Rob mentioned, particularly with our consumables, you kind of look at the major materials that go into those, it's a pretty good matchup in terms of what we use and what they can provide. Right.

Paul Knight

Okay. And then regarding the Lonza relationship, obviously they've been pretty vocal recently on your system. Are you seeing a pick up from Lonza kind of encouraging the industry to adopt. And B, It seems like you're essential at Lanza. Is that fair to say?

Robert Spignesi

Yeah, so in reverse order, I'll I'll let Lanza to, opine on how essential we are. Our opinion is, we are, clearly as we, as our goal, as is to build a new quality control infrastructure for pharmaceutical. Manufacturing globally, and the Lanza example is a very good example of it. But frankly, it's how a lot of our customers are seeking to deploy. Not every customer does a great job like Lanza in a white paper like this. But this is really the -- it's playing to our forehand, if you will, as far as how customers, when you hear these global deployments, this is how it looks to include the data benefits and interconnectivity with the the fundamental technology systems, and we do anticipate that we will continue to grow with Lanza and future deployments and future sites, through the coming quarters and years.

Sean Wirtjes

Okay thanks.

Robert Spignesi

Sure.

Operator

Brandon Smith, TD Cohen.

Brandon Smith

Hey guys, great congrats on the quarter, and on the great deal. It's good to see. Thanks for taking the questions. I wanted to actually first ask if you're able to tell us, how many systems Millipore actually committed to purchase over these first two years, and then actually just kind of given all the automation work with Lanza, just wondering if you have any updated thoughts on, potential AI integration or any evolving strategy on that front again just kind of given all the possibilities with the automation QC work.

Robert Spignesi

Thanks, Brandon. It's Rob. So we can't comment on the on the actual commitment for the for the commercial agreement. We can't quantify it, but as I mentioned in the In the remarks. And I think Sean followed it up as well, it will be significant beginning in 2026.
With regard to laws and more broadly our our approach to data, yeah, for the, for We view, at least with regard to where we operate inside these large companies, we're creating a large amount of digital data that didn't exist before. So the opportunity is part of our innovation strategy and.
This could intersect now in a collaborative way with Millipore Sigma. How we manage that data, how we can potentially pull it into an AI or cloud environment to provide enhanced insights and services for our global customers.
Let's just say it's it's a something on our radar and would be very exciting for not only us but for industry more broadly.

Brandon Smith

Okay, great. Thanks, guys.

Robert Spignesi

Well, thanks, Brandon. Okay, y'all, we're going to wrap up our call this morning. Thank you for joining us today and we look forward to speaking with many of you soon. Have a great weekend.

Operator

Ladies and gentlemen, that concludes today's call. Thank you for joining. You may now disconnect.