Q1 2025 Quantum-Si Inc Earnings Call

In This Article:

Participants

Katherine Atkinson; Senior Vice President, Commercial Marketing; Quantum-Si Inc

Jeffrey Hawkins; President, Chief Executive Officer, Director; Quantum-Si Inc

Jeffry Keyes; Chief Financial Officer, Treasurer; Quantum-Si Inc

Kyle Mikson; Analyst; Canaccord Genuity

Scott Henry; Analyst; Alliance Global Partners

Swayampakula Ramakanth; Analyst; H.C. Wainwright

Presentation

Operator

Good day and thank you for standing by. Welcome to the Quantum-Si first-quarter 2025 earnings call. (Operator Instructions) Please be advised that today's conference is being recorded.
I would now like to turn the conference over to today's speaker, Katherine Atkinson. Please go ahead.

Katherine Atkinson

Good afternoon, everyone, and thank you for joining us. Earlier today, Quantum-Si released financial results for the first quarter ended March 31, 2025. A copy of the press release is available on the company's website. Joining me today are Jeff Hawkins, our President and Chief Executive Officer; as well as Jeff Keyes, our Chief Financial Officer.
Before we begin, I would like to remind you that management will be making certain forward-looking statements within the meaning of federal security laws. These statements involve material risks and uncertainties that could cause actual results or events to materially differ from those anticipated. Additional information regarding these risks and uncertainties appears in the section entitled forward-looking statements of our press release. For a more complete list and description of risk factors, please see the company's filings made with the Securities and Exchange Commission.
This conference call contains time sensitive information that is accurate only as of the live broadcast date today, May 15, 2025. Except as required by law, the company disclaims any intention or obligation to update or revise any forward-looking statements. During this call, we will also be referring to certain financial measures that are not prepared in accordance with us generally accepted accounting principle or GAAP. A reconciliation of these non-GAAP financial measures to the most directly comparable GAAP financial measures is included in the press release filed earlier today.
With that, let me turn the call over to Jeff Hawkins.

Jeffrey Hawkins

Good afternoon, and thank you for joining us. On today's call, we will provide a business update and review our operating results for the first quarter of 2025. After that, we will open the call for questions.
I'll begin with a reminder of our three corporate priorities: To accelerate commercial adoption, deliver on our innovation road map, and to preserve our financial strength. Our first corporate priority is to accelerate commercial adoption. During the first quarter, we launched the Platinum Pro system and completed our first customer sales. Our first quarter revenue of $842,000 is an 84% increase over the first quarter of 2024, though this result was slightly below our expectations.
During the quarter, we observed a significant slowdown in new instrument purchases in the US academic market due to the ongoing market uncertainties related to NIH funding and indirect cost caps. We expect these uncertainties to continue to impact new instrument sales in the US academic market into at least the fall of 2025 when a federal budget is estimated to be approved by Congress. That said, our existing US academic customers continue to purchase consumables during the first quarter, and we have no indication from customers that this pattern will change.
Turning to other segments in the US market, we continue to believe that pharma, biotech and government laboratories represent a good opportunity for continued growth in terms of both new instrument sales and ongoing consumable sales. With the NIH funding uncertainties expected to persist for the foreseeable future, we are putting greater emphasis on the pharma and biotech opportunity with our US commercial team and distribution partner.
To that end, we are pleased to report that we have recently completed the training of Avantor, our North American distribution partner. We are working closely with the Avantor sales team as they build their sales funnels and begin progressing opportunities through the sales process.
Turning now to international markets. We exited the first quarter with 23 international distribution partners. Overall, our international business performed well during the first quarter, and we are pleased with the continued interest we are seeing from potential customers across all international distribution partner territories. We continue to believe that our low capital cost, simplified workflow and automated data analysis is a compelling option for researchers in these regions looking to integrate an advanced proteomics platform into their research.
While the NIH uncertainty may impact short-term commercial results, we are optimistic about the opportunity to continue to grow our customer base in pharma and biotech and across the countries covered by our international distribution network. Additionally, we remain confident in the long-term market opportunity in proteomics and the technology roadmap we are executing on to capitalize on that opportunity.
Our second priority is to deliver on our innovation roadmap. We continue to have high confidence in our technology roadmap and our R&D team's ability to deliver on that roadmap as they have done over the past two years.
As a commercial stage company, we interact with customers, prospective customers and distribution partners every day and consistently receive feedback that confirms our view that whole proteome sequencing is the long-term future in proteomics.
Our version 4 Sequencing Kit remains on track for a third quarter 2025 launch. We expect that this kit will further increase proteome coverage via increased amino acid detection and the addition of a new enzyme that is engineered specifically to provide high-efficiency cutting of the amino acid directly preceding a proline. We believe this combination of improvements will allow customers to analyze more peptides per protein and detect more amino acids within the peptides present, especially those positioned behind a proline.
Turning now to library preparation. We are pleased to share that we have made great progress in our innovation program aimed at enhancing library preparation performance and now expect to be able to release a version 3 of our Library Preparation Kit by the end of 2025. While we are still early in the development program, the initial data gives us confidence that there is a clear path to reduce the sample input requirement for our kit. We believe that our ability to lower the protein input requirement will enable our customers to pursue an even greater range of biological samples and proteins of interest and the early data suggests that we will be able to make a very meaningful improvement in this area.
Next, I would like to provide an update on the Proteus development program. As a reminder, Proteus incorporates a new instrument and consumable architecture that will offer significantly more reads per sample, more samples per run and greater workflow automation than our current platforms. We are pleased to report that we remain on track to successfully perform protein sequencing on a prototype Proteus system by the end of 2025. Hitting this milestone in 2025 sets us up well to deliver on the launch of Proteus in the second half of 2026.
In terms of interim milestones of the Proteus development program, we achieved two important milestones since our last call. First, we have been able to successfully demonstrate the full fabrication process from raw material to finished wafer. This was an important step as it provides us with confidence that we can produce the quantity of consumables that we need to support the ongoing development efforts.
Second, we have demonstrated a set of fluorescent dyes that are compatible with the new technology architecture, and we have enough distinct dyes to support moving our current sequencing chemistry over to the Proteus platform.
In addition, we are in the late stages of completing the delivery of additional dyes that proactively position us for an expanded set of amino acid recognizers that we anticipate bringing to market as part of the Proteus platform launch in the second half of 2026.
Finally, I would like to spend a few minutes updating you on the broader opportunity for our core technology beyond protein sequencing.
During our November 2024 Investor and Analyst Day, we shared data from our research initiatives that showed the vast capabilities of our core technology to be extended into other areas of proteomics beyond protein sequencing. Based on the data presented, we believe our core technology is the only commercially available technology that can enable single molecule, top-down and bottoms-up proteomics methods. Because of this, we believe that our Proteus platform and core technology will be capable of addressing the broadest range of proteomics analysis methods of any technology in the market today.
To accelerate the realization of that opportunity and in response to customer and partner interest, today, we released additional information about the application of our core technology to ultrasensitive protein detection. With only a modest amount of investment to date and using off-the-shelf affinity reagents, we have demonstrated sensitivity in the low femtomolar range working directly from serum and generating results in about two hours. This is all enabled on our low-cost Platinum Pro instrument and does not require any additional readout using PCR or NGS.
Through partnerships and collaborations with organizations that have highly optimized affinity reagents, we believe the assay performance would only improve from here. We are sharing this information today to make our capabilities more visible to the broader market and thereby accelerate the path to unlocking this capability via strategic partnerships and collaborations over the coming quarters.
Our third priority is to preserve our financial strength. While the current market uncertainty may impact short-term commercial results, we remain confident in the long-term market opportunity in proteomics and the technology roadmap we are executing on to capitalize on that opportunity.
We believe that we are the clear technology leader with the only commercially available next-generation protein sequencing platform, and we expect to continue to build upon that leadership position going forward. We have a strong balance sheet, and we'll continue to invest our capital in an efficient manner that maximizes long-term shareholder value.
I will now turn the call over to Jeff to review our financial results.