Jason Fredette; Senior Vice President, Investor Relations & Corporate Communications; Mersana Therapeutics Inc
Martin Huber; President, Chief Executive Officer, Director; Mersana Therapeutics Inc
Brian Deschuytner; Chief Financial Officer, Chief Operating Officer, Senior Vice President; Mersana Therapeutics Inc
Tara Bancroft; Analyst; TD Cowen
Charles Zhu; Analyst; LifeSci Capital
Michael Schmidt; Analyst; Guggenheim Securities
Jonathan Chang; Analyst; Leerink Partners
Colleen Kusy; Senior Research Analyst; Robert W. Baird & Co Inc
Andy Hsieh; Analyst; William Blair
Karina Rabayeva; Analyst; Truist Securities
Operator
Good morning and welcome to the Mersana Therapeutics first-quarter 2025 conference call. (Operator Instructions) I would now like to turn the call over to Mr. Jason Fredette, Senior Vice President, Investor Relations and Corporate Communications. Please proceed, sir.
Jason Fredette
Thank you, operator, and good morning, everyone. Before we begin, please note that this call will contain forward-looking statements within the meaning of federal securities laws. These statements may include, but are not limited to, those related to the potential clinical benefits of our product candidates and platforms, our clinical trial progress in design, addressable market opportunities, anticipated clinical milestones and data presentations and cash runway.
Each of these forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially from those projected in such statements. These risks and uncertainties are discussed in our annual report on Form 10-K filed with the Securities and Exchange Commission on March 3, 2025 and in subsequent SEC filings. Our filings are available at sec.gov and on our website, mersana.com.
Except as required by law, we assume no obligation to update forward-looking statements publicly even if new information becomes available in the future. On today's call, we have Mersana's Chief Executive Officer, Dr. Marty Huber; and our Chief Operating Officer and Chief Financial Officer, Brian DeSchuytner.
With that, let me turn the call over to Marty to begin the discussion.
Martin Huber
Thank you, Jason, and good morning, everyone. Let's begin by touching on last week's announcement of Mersana's strategic restructuring and reprioritization plan. This plan includes several cost savings initiatives, among them are the reduction of about 55% of our workforce across functions, the elimination of our internal pipeline development efforts, a reduction of other research activities and a narrowing of our clinical development work with Emi-Le to focus on breast cancer.
We will continue supporting Phase 1 dose escalation work for XMT-2056 and our ongoing collaborations. Our main objective, however, was to extend our cash runway into mid-2026 to give us the opportunity to generate important objective response rate and durability data for Emi-Le from both of our ongoing Phase 1 dose expansion cohorts.
Many of our colleagues learned last week that they will be departing Mersana today, and others will be leaving in the near term. I would like to take a moment to thank them for all they have contributed to our programs and our patient-centric culture.
Now let's move on to a very timely topic. Earlier this morning at the ESMO Breast Cancer 2025 Congress in Munich, Dr. Erika Hamilton, who heads up breast cancer research at the Sarah Cannon Research Institute, presented updated clinical data for Emi-Le, our Dolasynthen B7-H4 ADC. The presentation primarily focused on preliminary time-to-event data from patients with triple-negative breast cancer, or TNBC, who are enrolled in our dose escalation and backfill cohorts. Safety and tolerability data in this population remain consistent with those previously reported with no new safety signals.
Now before getting into the clinical activity data, it may be helpful to share a little context upfront. First, it's worth noting that research, as shown B7-H4 expression, is a negative prognostic factor in various cancers, including in TNBC. In other words, clinical outcomes in patients with higher B7-H4 expression are generally worse than those for patients with lower expression. Additionally, it is helpful to know what the performance is for today's standard of care in late-line TNBC, namely single-agent chemotherapy. A key reference for this is ASCENT, Trodelvy's registrational trial in relapsed and refractory TNBC.
In that trial, patients receiving chemotherapy achieved an objective response rate, or ORR, of only 5%. The median progression-free survival, or PFS was about seven weeks and median overall survival, or OS was about seven months. Those data were from patients who were naive to topo-1 ADCs. Ultimately, we believe that this is the type of time-to-event data that a new agent would need to beat in a potential randomized pivotal trial in post topo-1 TNBC for full approval. And given these low bars, we believe such a randomized trial would not take much longer than a single arm trial.
With that, let's briefly recap the clinical activity data presented this morning. The presentation focused on evaluable patients with TNBC, who received intermediate doses of Emi-Le ranging from about 38 milligrams per meter squared up to about 67 milligrams per meter squared. Importantly, more than 80% of these TNBC patients had received a prior topo-1 ADC. Among those patients with B7-H4 low tumors who received four or fewer prior lines of treatment, the ORR was 0%. The median PFS was 6.4 weeks, and the median OS was 5.7 months.
But among those patients with what we have initially characterized as B7-H4 high tumors who received four fewer prior lines of therapy, the ORR was 29%. The median PFS was 16 weeks, and the median OS had not yet been reached as of the data cutoff of March 8.
As a reminder, our current dose expansion cohorts are only enrolling TNBC patients who received four or fewer prior lines of therapy, including at least one prior topo-1 ADC. While some patients with B7-H4 low tumor expression are being enrolled, our primary focus is on the B7-H4 high TNBC population. And so while the sample size from dose escalation of backfill is small, today's presentation sheds further light on why we continue to believe Emi-Le could represent a meaningful improvement over today's standard of care for patients with post topo-1 TNBC.
The ESMO breast presentation also contained an update on clinical activity observed across all tumor types in dose escalation backfill cohorts as of that data cutoff of March 8. And 8 of 26 evaluable patients with B7-H4 high tumor expression who received intermediate doses of Emi-Le achieved a confirmed response for an ORR of 31%.
This is an increase from the 23% ORR that was reported based upon our December 2024 data cutoff. Further details are contained in the ESMO breast presentation, which can be accessed on the publication sections of our website at mersana.com. We will be sharing some additional clinical data from dose escalation and backfill cohorts across all tumor types based on that March 8 data cutoff in an oral presentation at ASCO in a couple of weeks.
So where do we stand with our expansion work with Emi-Le? Well, we're making great progress. Again, in expansion, we are focusing on patients with TNBC who have received one to four prior lines of therapy, including at least one prior topo-1 ADC. Enrollment in our initial expansion cohort that is receiving 67.4 milligrams per meter square dose of Emi-Le every four weeks has advanced rapidly in 2025.
As a reminder, we amended our clinical trial protocol in the first quarter this year with the goal of mitigating proteinuria related dose delays we had seen at higher doses of Emi-Le. These proteinuria management guidelines have now been adopted at our clinical sites.
I'm also happy to share that we recently initiated and have progressed patient enrollment in our second TNBC expansion cohort. These patients are receiving a starting dose of 44.5 milligrams per meter squared of Emi-Le on days 1 and 8 of the first four-week cycle, followed by 80 milligrams per meter square every four weeks. We chose this regiment for a few reasons. First, all four of the evaluable B7-H4 high patients who received the 44.5 milligram per meter squared, day 1, day 8 dose every four weeks in dose escalation of backfill cohorts achieved tumor reductions of at least 30%.
Second, we believe our recent protocol amendment will enable us to maintain dose intensity and tolerability for our 80-milligram per meter squared Q4 dose. And third, our PK work showed that exposures for this regimen are distinct versus our 67-milligram per meter squared every four-week dose, which we believe may be helpful in the spirit of Project Optimus.
As we continue advancing our work and expansion, we are also witnessing a series of developments that could significantly expand the post topo-1 patient pool. Up until now, in the breast cancer space, topo-1 ADCs have only been approved for relapsed and refractory patients. But in recent months, there have been multiple positive Phase 3 readouts for topos in the frontline setting. Focusing specifically on the TNBC, as we've noted before, global TNBC revenues for Trodelvy in 2025 are projected to exceed $1 billion.
Just a few weeks ago, positive top line results were shared from ASCENT 4, a clinical trial for the combination of Trodelvy and KEYTRUDA in frontline TNBC. This readout may enable Trodelvy to become the new standard of care for first-line PD-L1 positive TNBC and with results from the Phase 3 ASCENT 3 trial in PD-L1 negative patients, also expected in the weeks ahead, we believe the post-topo-1 TNBC patient population could expand substantially.
In summary, we remain excited about Mersana's prospects. We're making great progress with expansion enrollment, and we are looking forward to sharing initial clinical data from expansion in the second half of this year.
With that, let's turn the call over to Brian for our financial review.
Brian Deschuytner
Thank you, Marty. Beginning with our balance sheet. We ended the first quarter of 2025 with $102.3 million in cash and cash equivalents. due in part to the restructuring and reprioritization plan we announced last week. We expect that our capital resources will enable us to support our current operating claim commitments into mid-2026.
Please note that our cash runway guidance does not assume any future milestone payments that we may earn from our current collaborations or proceeds that we may realize from future collaborations. Net cash used in operating activities for the first quarter of 2025 was $29.3 million.
Turning to our income statement. Collaboration revenue for the first quarter of 2025 was $2.8 million compared to $9.2 million for the same period in 2024. The year-over-year change was primarily related to reduced revenue recognized under our collaboration and license agreement with J&J and Merck KGaA.
Research and Development expenses for the first quarter of 2025 were $18.3 million compared to $18.7 million for the same period in 2024. For the most recent quarter, approximately $1.4 million of this spending was related to noncash stock-based compensation. The year-over-year change was primarily related to our lower head count and related employee compensation costs partially offset by an increase in costs related to Emi-Le clinical development activities.
General and administrative expenses for the first quarter of 2025 declined to $8.9 million compared to $11.6 million during the same period in 2024. Approximately $1.3 million in noncash stock-based compensation expenses were included in G&A for the most recent quarter.
The year-over-year decline was primarily related to a reduction in consulting and professional services fees as well as the company's lower head count and related employee compensation costs. And finally, Mersana's net loss for the first quarter of 2025 was $24.1 million compared to a net loss of $19.3 million for the same period in 2024.
That concludes our business update. Operator, would you please open the call to questions from the audience.
Operator
(Operator Instructions)
Tara Bancroft, TD Cowen.
Tara Bancroft
Hi, good morning and thanks for taking the question. So I was hoping you could expand a little bit more even qualitatively on the high dose, especially regarding safety and the updated protocol. I know you mentioned that the PK profiles were pretty distinct, but I'd love to hear more about that. And if an update here will be included in the ASCO update at all. Thanks so much.
Brian Deschuytner
Thanks, Tara. Well, just last one first. This is part of the second dose level, the 44.5 is part of expansion. And just to be clear, the data we are sharing at ASCO is based on escalation of backfill only. There is not going to be expansion data at ASCO.
So these data would not be included in that presentation. With regards to the rationale, I think I'm going to work backwards to the PK, one of the things you want to look for when you study a second dose is make sure that from an exposure point of view, it's a discrete dose level, and it's not overlapping.
In other words, it needs to be a meaningfuly higher dose because if you think about the Project Optimus project, if you have two doses that are 80% of the patients are overlapping an exposure, it's really not a second dose. So we were looking for a dose that is meaningfully higher than 67.4. So the dose we're putting forward at 44.5-day 1 day followed by 80 is a meaningfully higher exposure than you achieved with 67.
And then the final part of, why we believe it's doable is when we evaluated our data, one of the observations we found is the 44.5 day 1, day 8 was the most effective dose in ensuring a tumor reduction at week six. So it clearly had -- I mean I said four out of four patients who were B7-H4 with measurable to it to baseline who got that dose, we fixed. The problem we had with 44.5 was the proteinuria also resulted in patients interrupting treatment. So now we believe with the proteinuria mitigation efforts in place that we will be able to maintain it.
Now the question then is, well, why did you go from a day 1, day 8 to then an 80. Well, an 80 is also a meaningfully higher exposure. But fundamentally, you do run into a problem of trying to do a day 1, day 8 and maintaining that every cycle just gets to be challenging, whereas 80 every four weeks gives you an exposure in the ballpark of 44.5 day 1, day 8, But it's much -- when we talk to our investigators, there was a lot of negative feedback about trying to maintain a day 1, day 8 schedule on an ongoing basis. But we do think it's worth it trying to get it in for that -- or didn't get into that first cycle because that really is our best shot at efficacy.
Tara Bancroft
Okay, great. Thank you so much.
Operator
Charles Zhu, LifeSci Capital.
Charles Zhu
Hey. Good morning, everyone. Thanks for taking the questions. Congrats on the progress and nice to see some of these response rates ticking upwards a bit. I have a question regarding maybe some of the ASCENT 3 and ASCENT 4 studies, either having already read out or about to read out. How might these -- assuming a sense the results are successful, like change standard of care and impact, if at all, your clinical development claims in the post topo setting?
And really, what I'm getting at here is, would you expect any sort of like different patients based on characteristics or outcomes based on whether or not they get this new standard of care versus getting the prior/current standard of care? Thank you.
Brian Deschuytner
Sure. Maybe I'll take that one. As you know, our expansion cohort is exclusively looking at post topo-1 TNBC. And so I think while we certainly have activity, and we've shown this in the January data disclosure in non-topo pretreated patients in the US and in Western Europe, the penetration of these topo delivering ADCs has been very, very rapid.
Each of the recurrent setting, as Marty noted in his remarks. I think what this provides the opportunity for is the earlier those agents are used, the more and more patients fall into this post topo-1 category. And we know that very uniquely we retain activity in that space. In fact, we've been deliberately studying that space because it's one of the highest unmet need in breast cancer.
What do you do once you induced resistance phenotype in a patient post topo-1? It's a serious question for many of the physicians. We have been uniquely in the space for B7-H4, recruiting those types of patients to ask that hard question. And so we view this as a very positive development for patients and for the size of the opportunity that we're pursuing.
Charles Zhu
Got it. Great. Thank you.
Operator
Michael Schmidt, Guggenheim.
Michael Schmidt
Hey, good morning. Thanks for taking my questions. Yeah, maybe just a couple of follow-ups. Again, nice to see the additional two responses in the -- at the intermediate dose. Could you just comment on what types of patients those were? Were those two TNBC patients or perhaps some of the other histologies? And then yeah, just curious if you could provide some qualitative sort of perhaps comment on the impact of some of the product or amendments that you've implemented to manage some of the proteinuria and prophylaxis.
How has that sort of -- what was the experience with that so far? And has that indeed resulted in pre-lowering, proteinuria or delay some of these treatment holes? And then lastly, could you just give us a sense of enrollment at the 67-milligram cohort and how that's been progressing and how substantial this update in the second half later this year will be. Thanks so much.
Martin Huber
I'm going to start work backwards. So on the 67 enrollment, we're not giving further guidance. I think what we -- suffice it to say, we've seen sufficient enrollment that we felt comfortable issuing a new guidance. We kind of -- since we kind of went out of guidance for the year because we'd actually achieved all the stuff we see do.
So we decided that when we looked at our enrollment, we have enough patients that we felt confident we would have a data set. And one of the questions we want to do is make sure we have a data set that had enough durability because that's, as you all recall, from our initial data set that was one of the questions.
So I think as far as -- we're not giving actual sample sizes yet. But I think the fact that we've switched from 67 to the second dose should indicate we're doing fine on enrollment. And I think for any of you who happen to get up at 2 AM and listen to Erika's call. And from our people on the ground in Munich have been telling us, the investigator enthusiasm has been hot, and we're seeing that in the enrollment.
So I think this niche of post topo now, we've clearly become if you can -- if you have this trial available for your patients, you're putting your patients on it. So this is -- so that's why I think we're comfortable putting out the new guidance for second half.
With regards to the proteinuria, once again, we're not giving a data yet. And I think probably a couple of things that are important to understand about that is the mitigations that we're doing, we do not anticipate them ever taking proteinuria to 0. So we want to be very clear. Our expectation is you're still going to see an AE of proteinuria in these patients. What it is about is managing the other consequences of avoiding the development of serum hypoalbuminemia changes in creatinine.
And I think we're at the point now we're confident enough in our mitigation efforts that we are comfortable opening the expansion at the new dose and regimen. We will at some -- when we share the data on this dose in the second half, then we can get into more details of exactly what that looks like.
Jason Fredette
And the first question was the 31% ORR --
Martin Huber
Tumor types. Yeah, those both were ACC 1s. But as far as the more details of that, we -- in our upcoming ASCO presentation, whereas ESMO kind of covered the focused-on TNBC, Erika is going to focus on the other tumor types, including the 31% at the ASCO presentation. and a few more things that we can't disclose yet on that base.
Michael Schmidt
Right. Thank you.
Operator
(Operator Instructions)
Jonathan Chang, Leerink Partners.
Jonathan Chang
Hi, guys, good morning. Thanks for taking my questions. First question, are there additional dosing regimens that could be further evaluated beyond dose A and B in the expansion? Or have you settled on these two dose cohorts? And second question, can you help set expectations on the upcoming ASCO presentation? What could we learn at ASCO relative to the disclosure today? Thank you.
Brian Deschuytner
First of all, with regards to the doses, these are the two doses that we are taking into expansion. We do not anticipate any others. Obviously, we always were data-driven if we learn something new from the data. But the go-forward plan is that it would be either of these two doses.
And in fact, that's one of the reasons we kind of scheduled on this kind of loading that switched to 84 because we believe doing the loading for one cycle and then switching to 80 Q4 is a viable dosing schedule to take forward assuming the data supports it. But we do not -- we've obviously looked at other doses and schedules as part of our backfill. But at this point in time, we don't have any plans to take any of those forward.
And with regards to the ASCO presentation, I think really probably knowing that companies have gotten in trouble for violating embargo, we don't. I mean this is our first oral presentation as a company. And the last thing I would hate to do is be the guy who lost it because I blew it embargo. But the thing I think we can be very clear on to set expectations. This is the backfill and escalation data. There is not going to be expansion data at ASCO.
Michael Schmidt
Understood. Thanks for taking my questions.
Operator
Colleen Kusy, Baird.
Colleen Kusy
Hi, good morning. Congrats on all the progress and thanks for taking our questions. Marty, I think you mentioned something about a randomized Phase 3 taking that much longer than a single arm. So could you just provide a little bit more color on what you're thinking on a potential pivotal study? And I have a follow-up, please.
Martin Huber
I mean a lot of people ask us questions of, is your response rate going to be high enough for an accelerated approval. And I think one of the things we're looking -- we think that's actually kind of a relevant question. because fundamentally, if you can do a randomized trial in a similar time frame as a nonrandomized trial, that's always the better way to go.
And there's -- I'll give you three reasons to that. One is, from a regulatory point of view, and now you have to think beyond the US on a global basis, a randomized trial, you could file anywhere. A lot of companies have decovery to these accelerated approval strategies with a single log trial, and then you can't go anywhere else and then you're kind of stuck waiting for a randomized trough.
The second is you still end up having to do the randomized confirmatory trial. And if that randomized confirmatory trial, it's not well underway or near complete, you can get in trouble of not getting an approval because you haven't progressed your confirmatory trial. And that's a point where the agency has gotten very, very sticky. They really, really want to know that the definition of well underway. It's getting -- they basically want to trial is going to read out before they approve you.
And then the other area where it comes in, and this is one of the things we were very pleased with sharing at ESMO is things like if you look at diseases like TNBC, post topo especially, where patients are progressing in 6 weeks and dying in six months or less is what's important for physicians is to understand not only the response rate, but stable disease as well.
In TNBC post-topo a patient who doesn't progress in 18 weeks is deriving a meaningful benefit from the treatment because we know the natural history of that patient as they progress in six weeks. And then finally, you can actually, in a randomized trial in TNBC by the time you finish enrollment, you'll probably already have enough end points for PFS.
So you could basically complete your enrollment and almost turn around and look at your PFS endpoint the next day. And then your survival endpoint is literally coming in within months of that. So we think there's an opportunity with a randomized trial to avoid a confirmatory trial and get OS data, even if it's a secondary endpoint rapidly.
And then once you have that data set, we think that makes it all this churn you're seeing at the FDA about are they going to accept randomized trials or do they want placebo-controlled or all that nonsense just goes away if you run a randomized trial because you're walking in with what everybody would agree is the gold standard of trials. Just to be clear, we have not had a formal regulatory advice on this. But on that point, I think I would be shocked if the FDA wouldn't accept a randomized trial with PFS and OS as you're in place.
Colleen Kusy
Got it. Okay. Super helpful. And then can you -- in that context, can you just talk about the cutoff for B7-H4 expression and how much additional work needs to be done before you feel like you can totally confirm that?
Martin Huber
We're doing that work in expansion. There were -- would you switch to a pre-commercial assay; there were a few tweaks in the assay between escalation and backfill and expansion. So in expansion, it is possible that the TPS score comes out to be a slightly different place. But I think what's important to understand is, even if the TPS score shifts a little bit, we still fully anticipate that 40% to 50% of patients are going to be positive. So the actual score may change a little bit, but we would be surprised if the percent of patients who are positive dramatically changed.
Brian Deschuytner
And that's probably an important point as you think about the competitive landscape because people have different specifications around their research assays, the specification doesn't matter so much sustaining conditions, a standing time the temperature. What you're looking for in B7-H4 is about 40% to 50% of the population. And so regardless of what -- someone describes the conditions of their assay, they're likely identifying the same patients.
Colleen Kusy
Got it. That's great. Thanks for taking the questions.
Operator
Andy Hsieh, William Blair.
Andy Hsieh
Thanks for taking our questions. Two quick ones from us. One is about the post-topo dynamic. I think at the conference, Dr. Tolaney presented almost 200 patients worth of data. showing similar PFS for the intermediates or after an intermediary chemo for topo ADC rechallenge.
And so that, I guess, from my perspective, statically on resistant phenotype is more longer term, I'm curious about your take on that data. And then secondarily, in the January update for the triple-negative cohort, there were three patients with treatment ongoing. I'm just curious about the status of these three patients for the March update. Thank you.
Martin Huber
With regard to your first question, I mean I'm not in Munich. I mean I stay behind because of the restructuring and the earnings. So I cannot -- I want to be careful commenting on my presentation, which I did not see. So I'll have to go back and look at that. We do have people on the ground have to -- we'll find out from them.
With regards to the details of the ongoing status. I think I would defer that, as I said to the ASCO, we will be giving an update -- the March update for all patients at the ASCO presentation, and I really don't want to front run that.
Operator
Asthika Goonewardene, Truist.
Karina Rabayeva
Hi. This is Karina, for Asthika. Thanks for taking my question. I had a follow-up on the B7-H4 expression. What proportion of patients have been expression rate in your previous presentation, you have 40 out of 130 patients. So should we assume around roughly 30% of the population.
Martin Huber
I think we for TNBC, we're comfortable that a number will be somewhere between 40% and 50% of the population.
Karina Rabayeva
Okay. So 40% to 50%. And then also regarding the proteinuria medication strategies for the ACE inhibitor prophylaxis, is that initiated only once the patient exhibits size of proteinuria or at a specific grade threshold?
Martin Huber
In the new amendment that has now been adopted at most of the sites, you are encouraged to start that prophylactically prior -- I mean, basically at the initiation of treatment unless the patient has a contraindication for the ACE arm.
Karina Rabayeva
Okay. Thank you.
Operator
(inaudible) BTIG.
Hey, good morning. Thank you for taking the question. Maybe two quick questions from me. With the 67.4 and 44.5 mg doses now moving forward in expansion, what would you ultimately want to see from a target product profile perspective to justify moving 44.5 over the other dose and into pivotal studies? And just in terms of the expansion update later this year, will it be strictly in TNBC patients? Or could we also expect to see, say, ovarian or endometrial patients for that update? Thanks.
Martin Huber
With regards to your first question, I mean, with -- if the efficacy for the higher dose is not meaningfully better than Q4, 67 Q4 is the dose we would take forward because it's just it is the Prodea is much less of an issue there, and it's just a fairly straightforward and easy regimen to do. The intent of the higher dose intensity upfront is getting patients into response faster, which is important and a very aggressive disease like TNBC, especially these late line post topo patients. What -- with regards to the -- your other question was -- sorry --
Just in terms of the expansion --
Martin Huber
And actually, this is -- I'm glad you asked that because this is one of the areas I think we probably did the impact of restructuring, when people are saying, what did we stop doing as part of this, one of the things that we are not doing is we originally had planned to be starting multiple extensions across multiple tumor types. And so one of the reasons we can get by with a smaller organization is it's going to be a very breast cancer-focused expansion program.
So the ovarian and endometrial data that we have already in backfill and escalation that will get the ASCO presentation, but there will not be in 2025. new expansion data beyond breast cancer. And that is just an unfortunate consequence of extending cash runway. But we still want to look at those two indications. It's just we had to prioritize at this point in time.
Thank you.
Operator
This concludes our question-and-answer session. I would like to turn the conference back over to Dr. Marty Huber for any closing remarks. Please go ahead, sir.
Martin Huber
Thank you, operator, and thanks, everyone, for dialing in. We look forward to seeing many of you in Chicago and ASCO in a couple of weeks. That concludes our call. Thank you.
Operator
The conference has now concluded. Thank you for attending today's presentation. You may now disconnect.
