INTASYL Compound RXI-231: a promising approach to treatment of hyperpigmentation
Marlborough, Massachusetts--(Newsfile Corp. - January 2, 2025) - Phio Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage biotechnology company developing therapeutics that use its INTASYL® siRNA gene silencing technology designed to make the body's immune cells more effective in killing cancer cells. Phio announced today the publication of research entitled, Self-delivering RNAi Compounds for Reduction of Hyperpigmentation, in the December, 2024 issue of Clinical, Cosmetic and Investigational Dermatology.
The article presents proof-of-concept data for RXI-231, an INTASYL compound designed to target and reduce tyrosinase (TYR) gene expression. RXI-231 significantly reduced tyrosinase mRNA expression, and correspondingly reduced in melanin content in both normal human melanocytes and the 3D human epidermal culture, Melano Derm model. Application of INTASYL RXI-231 every other day visibly reduced pigmentation in the 3D epidermal cultures. RXI-231 was also evaluated using the MatTek EpiDerm Skin Irritation model which confirmed its non-irritant profile. While further characterization and clinical testing is needed, RXI-231 shows promise in treating hyperpigmentation disorders.
Clinical, Cosmetic and International Dermatology is an international, peer-reviewed journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Key topics for the journal include normal and pathological process in skin aging, their modification and treatment, as well as basic research into the histology of dermal and dermal structures that provide clinical insights and potential treatment options
"We are delighted to see this publication which presents a summary of INTASYL compound RXI-231's uniqueness in addressing its selective targeting of TYR gene expression, and underscores the innovative and expansive potential of INTASYL compounds in dermatological conditions," said Robert Bitterman, CEO, Phio Pharmaceuticals.
About Phio Pharmaceuticals Corp.
Phio Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage biotechnology company advancing its proprietary INTASYL siRNA gene silencing technology to eliminate cancer. INTASYL can target and silence virtually any gene with high degree of specificity across a wide range of cell types and tissues. INTASYL is designed to enhance the ability of immune cells to more effectively kill tumor cells. INTASYL has also demonstrated enhancement adoptive cell therapy. Notably, INTASYL is a self-delivering RNAi technology focused on immuno-oncology therapeutics without the need for formulation enhancements or manipulations to reach its target.
Phio's lead clinical program, PH-762, is an INTASYL compound that silences PD-1. PH-762 is a potential non-surgical treatment for skin cancers. The on-going Phase 1b trial (NCT# 06014086) received FDA clearance for an Investigational New Drug Application to evaluate PH-762 in the treatment of cutaneous SCC, melanoma and Merkel cell carcinoma in second quarter of 2023.
For additional information, visit the Company's website, www.phiopharma.com.
Forward-Looking Statements
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