OSE Immunotherapeutics Presents Preclinical Updates in Immuno-Oncology at AACR Annual Meeting 2025
OSE-CYTOMASK®,a new CIS-Demasking1 cytokine bispecific technology.
CLEC-1, a novel immune checkpoint target.
NANTES, France – April 3, 2025, 6:00 p.m. CET - OSE Immunotherapeutics SA (ISIN: FR0012127173; Mnemo: OSE), a biotech company dedicated to developing first-in-class therapies in immuno-oncology and immuno-inflammation, today announced that the latest preclinical data on its novel OSE-CYTOMASK® CIS-Demasking cytokine technology and on the CLEC-1 immune checkpoint target, have been selected for poster presentation at the American Association for Cancer Research (AACR) Annual Meeting being held on April 25 – 30, 2025, in Chicago.
Aurore Morello, Head of Research and Director of R&D programs, OSE Immunotherapeutics, comments: “We are very happy to present the latest advancements from two of our ground-breaking preclinical programs, showcasing our unwavering commitment to innovative research. Our novel OSE-CYTOMASK® technology has demonstrated remarkable preclinical efficacy and an improved tolerance profile, positioning this drug candidate as a potential first-in-class cytokine treatment with a superior therapeutic index in oncology. Moreover, its potential extends beyond oncology, offering promising applications in autoimmune and inflammatory diseases. Our collaborative research with Dr. Elise Chiffoleau’s CR2TI(Center for Research in Transplantation and Translational Immunology) research team in Nantes 2 on the immune checkpoint target CLEC-1 has confirmed the therapeutic efficacy of anti-CLEC-1 antibodies, both as monotherapy and in novel combinations. This provides compelling evidence to support the further development of a new cancer immunotherapy, reinforcing our dedication to advancing transformative treatments for patients.”
OSE-CYTOMASK® is a technology that helps make cancer treatments safer and more effective. It works by attaching a special linker sequence that can mask a molecule called a cytokine, which is part of the immune system. This masking technology keeps the cytokine inactive until it reaches the right type of immune cell, like PD1-expressing T cells, which are often found in tumors.
When the cytokine reaches these specific cells, the mask is removed, and the cytokine becomes active. This targeted approach helps to reduce side effects and improve the effectiveness of the treatment by only activating the right immune cell into the tumor microenvironment.
The poster presentation titled “Cis demasking cytokine technology improves therapeutic index of immunocytokine” explains how this technology can make cancer therapies more precise and safer by reducing unwanted immune activity outside of tumors and focusing the treatment on the cancer cells.
CLEC-1 is a new type of immune checkpoint, which is a receptor found on certain myeloid cells and endothelial cells. It can block important immune functions that help fight cancer, making it harder for the body to attack tumors.
The poster presentation titled “First in class Anti-CLEC-1A myeloid checkpoint antibodies for the treatment of solid tumors with monotherapy and combination therapy efficacies” highlights recent positive results from preclinical studies. These studies show how CLEC-1 can weaken the immune system's ability to fight cancer. The findings suggest that targeting CLEC-1 with specific antibodies could be a promising new treatment option for cancer, either alone or in combination with other therapies.
OSE Immunotherapeutics is a biotech company dedicated to developing first-in-class assets in immuno-oncology (IO) and immuno-inflammation (I&I) that address the unmet patient needs of today and tomorrow. We partner with leading academic institutions and biopharmaceutical companies in our efforts to develop and bring to the market transformative medicines for people with serious diseases. OSE Immunotherapeutics is based between Nantes and Paris and is quoted on Euronext.
Additional information about OSE Immunotherapeutics assets is available on the Company’s website: www.ose-immuno.com. Follow us on LinkedIn.
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1 CIS-Demasking:Bispecific antibodies (*) have the capability to target cells either in a Cis- targeting (on the same cell) or in a Trans-binding orientation (between two different cells). Cis-Demasking bispecific technology targets two antigens expressed on the same cell, with one masked modality (eg. Cytokine) and enabling conditional activity of the cytokine on the desired immune cell types upon antibody binding. (*) Segués A. et al. International Review of Cell and Molecular Biology 2022. 2 Collaborative academic program between OSE Immunotherapeutics and Dr Elise Chiffoleau’s research teams (Center for Research in Transplantation and Translational Immunology (CR2TI), UMR1064, INSERM, Nantes University at Nantes University Hospital, https://cr2ti.univ-nantes.fr/research/team-1).
