Strong Insider Buying Makes These 2 Stocks Attractive

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Profitable investing is all about making the right choices and finding the stocks to build a portfolio that will generate positive returns no matter what happens. The challenge now can be summed up in the range of headwinds pushing against the markets. Investors have to contend with high inflation, and the prospect of higher rates going forward, as Fed chair Powell has indicated that the central bank’s priority will be to tame it.

But that doesn’t mean there aren’t opportunities to seek out in the current environment; one way to find them is by taking cues from the insiders - the corporate officers with responsibility for ensuring company profits as well as stock performance, enforced by Board and shareholder oversight.

Using the Insiders’ Hot Stocks tool, we’ve found two equities that offer investors strong upside potential, according to Wall Street analysts – and have also picked up large buys from those in the know. Let’s see why the insiders think now is the right time to pounce.

Cassava Sciences (SAVA)

We’ll start with Cassava Sciences, a clinical stage biopharmaceutical firm focused on the detection and treatment of Alzheimer’s disease. Cassava has one leading drug candidate, simufilam, which is undergoing Phase 3 clinical trials, as well as a diagnostic product, SavaDx, designed to detect Alzheimer’s through an ordinary blood draw.

Cassava has faced some idiosyncratic headwinds recently, due to a regulatory investigation into charges of data manipulation of the simufilam clinical trials. Last month, however, the company was fully cleared of those charges in a study published by the peer-reviewed Journal of Prevention of Alzheimer’s Disease (JPAD).

The JAPD review was not Cassava’s only good news recently. The company reported that simufilam now has over 400 patients enrolled in two Phase 3 clinical studies, and that interim data on the first 100 patients to complete the open label study showed that simufilam was safe and well tolerated. Also of note, 63% of patients in that open label study showed a significant improvement in cognitive testing. An additional 21% of patients showed a cognitive decline of less than 5 points. The company expects the open label study to be completed by 4Q22.

In his review of this stock, H.C. Wainwright analyst Vernon Bernardino points out the JPAD review, and goes on to say, “We note that similarly, in December 2021, the Journal of Neuroscience (JN) also investigated and found no evidence of data manipulation by Cassava in a 2005 paper published in JN. Lastly, in November 2021, JN also investigated and found no evidence of simufilam data manipulation in a paper JN published in July 2012. We see these critical reviews as positive for Cassava, as they confirm allegations of data manipulation were false and removed a negative overhang that has depressed Cassava stock. Importantly, they reconfirm that simufilam has a positive effect on biomarkers of AD. We believe conclusions by these journals and support simufilam’s continued clinical study in AD…”