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Numerous Independent Groups Presented Data that Supports Apabetalone's Potential Cardioprotective Benefits at European Society of Cardiology Congress 2024

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Numerous GLP-1 RA and SGLT2i presentations touted their clinical results, providing continued excitement for our BETonMACE program, which observed a non-prespecified 63% reduction in MACE and heart failure hazard among patients taking next-generation glucose lowering drugs

Calgary, Alberta--(Newsfile Corp. - September 3, 2024) - Resverlogix Corp. (TSX: RVX) ("Resverlogix" or "the Company") today announced its presentation at the European Society of Cardiology ("ESC") Congress 2024 in London, UK on September 1, 2024. Resverlogix's Chief Scientific Officer, Dr. Ewelina Kulikowski, gave a presentation entitled: "Epigenetic BET inhibitor apabetalone counters inflammatory and fibrotic processes in activated cardiac fibroblasts providing insight into reduced hospitalizations for heart failure in BETonMACE trial".

"The importance of the presentations at this year's ESC congress is that they position apabetalone as a drug with potential benefits across various metabolic diseases such as cardiovascular disease, chronic kidney disease, inflammation, & diabetes," said Donald McCaffrey, President & CEO of Resverlogix. "For the past several years Resverlogix has led the way in developing a program to tackle the underlying causes of these diseases, cross treatment boundaries, and - in conjunction with other treatments - deliver real benefits for patients. We were pleased to see other groups promote this combinatorial approach at this year's ESC event."

The conference featured presentations on next-generation glucose lowering drugs, such as sodium-glucose cotransporter-2 inhibitors ("SGLT2i") and glucagon-like peptide-1 receptor agonists ("GLP-1 RA"), focused on their additional cardiovascular benefits in diabetic and chronic kidney disease ("CKD") patients. Current ESC guidelines on the treatment of cardiovascular disease in diabetic patients reports a pooled 10% hazard reduction in major adverse cardiac events ("MACE"; a composite of cardiovascular death, heart attack, and stroke) with SGLT2i treatment, and a 15% MACE hazard reduction with GLP-1 RA treatment. Based on data from the Phase 3 trial, BETonMACE, apabetalone treatment reduced the hazard of MACE and hospitalization due to heart failure by 63% (p=0.0002), among patients taking next-generation glucose lowering drugs, in a post-hoc analysis.

"The data presented at the ESC Congress indicates that patients receiving the best currently available treatments still face significant risk of cardiovascular events," said Mr. McCaffrey. "Our Phase 3 results suggest that apabetalone and SGLT2 inhibitors - in combination - can further reduce the risk of events, and we believe we will conclusively demonstrate this in our upcoming BETonMACE2 trial."


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