Notox Announces Extension of Cleveland Clinic License and Medical Advisory Board Appointments

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Richmond Hill, Ontario--(Newsfile Corp. - March 15, 2022) - Notox Technologies Corp. (OTC: NTOX) ("Notox" or the "Company") is pleased to announce that the Company has entered into an amendment with the Cleveland Clinic Foundation (the "Clinic") and Notox Bioscience Inc., the Company's wholly owned subsidiary ("NBI"), regarding the exclusive license agreement between the parties (the "License Agreement").

The License Agreement, as amended, grants NBI the exclusive license to certain patented intellectual property of the Clinic relating to the treatment of a neuromuscular defect developed by Dr. Frank Papay, and in particular, the ability to produce, sell, improve and modernize products that incorporate such intellectual property in the fields of aesthetics, drug free pain management, body contouring and perspiration control.

The material terms of the amendment, which follows previous amendments dated effective July 30, 2013 and July 1, 2016, extend the deadline for NBI to achieve the first commercial milestone (the submission of regulatory filings to applicable authorities) to December 31, 2023, and require NBI to begin completing partial reimbursements of the Clinic's approximately US$215,000 in accrued patenting costs as of February 2, 2022 at the rate of US$25,000 per calendar quarter.

The License Agreement is valid until the expiration of the last to expire of certain patents. Pursuant to the License Agreement, we are required to pay the Clinic a royalty based on the sale of certain products, a milestone payment upon the first commercial sale of the first such product and a percentage of any sublicensing revenues.

"I am extremely proud of Notox's progress during the past 24 months in the face of numerous COVID-19 restrictions and related limitations," commented Zoran Konević, the Chairman and CEO of Notox. "This amendment indicates that our primary partnerships are stronger than ever and it has also been comforting to receive such fantastic support. In particular, I would like to thank David Weinrauch for his leadership and loyalty, as well as all our key shareholders."

In addition, Notox is pleased to announce that, further to its news release dated December 15, 2021, the Company has appointed the first two members of its new Medical Advisory Board, Dr. Frank Papay and Dr. Tyler Kendall.

Dr. Frank Papay, MD

Dr. Papay is a biomedical engineer and surgeon who holds dozens of U.S. patents and has received more than 50 industry honors-including the Medal of Merit from Ohio University, the WebMD Health Hero Award in Science and the George and Grace Crile Surgical Award. Currently, Dr. Papay is professor of surgery at the Lerner College of Medicine at Case Western Reserve University and Chairman of the Dermatology and Plastic Surgery Institute at the Cleveland Clinic.