Global Bispecific Antibody Market To Witness More Than 400% Absolute Sales Growth By 2029 Says Kuick Research
Delhi, March 17, 2024 (GLOBE NEWSWIRE) -- Global Bispecific Antibody Market Opportunity Insight 2029 Report Highlights:
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Global Market Forecast Till 2029: > USD 36 Billion
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Approved Bispecific Antibodies: 11
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Yearly & Quarterly Sales Insight
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Global & Regional Sales Insights
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Insight On Bispecific Antibodies In Clinical Trials: > 600 Bispecific Antibodies
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Global Bispecific Antibodies Clinical Trials By Company, Indication & Phase
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Fast Track Approval, Orphan Designation & Priority Status Insights
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Approved Bispecific Antibodies Pricing & Dosage Analysis
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Top 30 Companies Developing Bispecific Antibodies Competitive Insight
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800 Pages Clinical & Commercial Opportunity insight
Download Report:
https://www.kuickresearch.com/report-bispecific-antibody-market-bispecific-antibodies-market
Navicixizumab is a pioneering bispecific monoclonal antibody that targets both the Notch ligand delta-like 4 (DLL4) and the human tyrosine kinase vascular endothelial growth factor (VEGF). This unique dual targeting approach holds potential anti-angiogenic and antineoplastic capabilities. The rationale behind this combination stems from the fact that DLL4 expression is highly restricted to the vascular endothelium, and DLL4/Notch signaling is a crucial requirement for the development of functional tumor blood vessels. Additionally, the expression of the pro-angiogenic growth factor VEGF is associated with tumor angiogenesis, tumor cell proliferation, and invasion. By simultaneously targeting these two key players in tumor angiogenesis, Navicixizumab aims to disrupt the intricate signaling pathways that fuel tumor growth and progression.
The anti-DLL4 component of navicixizumab specifically targets DLL4, binding to it and preventing its interaction with Notch receptors. This inhibition of Notch-mediated signaling and gene transcription has a twofold effect: it potentially blocks tumor angiogenesis and inhibits tumor cell growth. Concurrently, the anti-VEGF moiety of navicixizumab binds to VEGF, preventing it from binding to its receptor. This blockade of VEGF-mediated signaling further impedes the growth and maintenance of tumor blood vessels. Through this dual mechanism of action, navicixizumab aims to disrupt the complex signaling pathways that drive tumor angiogenesis and progression, simultaneously targeting two key players in the process.
Navicixizumab is currently under development by Mereo BioPharma in collaboration with OncXerna Therapeutics, with the potential application in the treatment of post-platinum ovarian cancer. A Phase 1b dose-escalation clinical trial, now completed, aimed to assess the safety and efficacy of combining paclitaxel with navicixizumab. The results demonstrated promising clinical activity in both bevacizumab-treated and bevacizumab-naive patients with platinum-resistant ovarian cancer, with manageable toxicity.