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Our pediatric study will be reading out very shortly here at the end of Q4, and we had a strong financial position with $268 million in cash, and we have $15 million in non-GAAP operating income for the quarter. We're leaving here in Q3 in a very strong financial position as we get ready to fund our innovation here with clofazimine-101 and 201 moving forward. Now let me bridge over to clofazimine-101. As we look at the clinical development program, there's a significant unmet need in NTM lung disease due to current options having very severe limitations on both efficacy, safety and tolerability.

We believe oral clofazimine has been part of the guideline since 2020 and by developing an inhalation suspension, we have a great opportunity to put more drug into the lung really at the site of infection while minimizing the systemic exposure, which is really important as we think about the clofazimine-related side effects of skin discoloration, QT prolongation and drug accumulation in the organs. We also believe our convenient dosing cycle of 28 days on and 56 days off will provide us a competitive advantage. Unfortunately, as we look out in the space, MannKind is one of the last remaining companies outside of Insmed investing in NTM at this point due to the failures of several competitors this past year. I want to remind you of the ICoN-1 Phase 3 study design, we're now able to have about 25% of sites activated.

And when you think about this trial, we're aiming for about 180 patients as a primary endpoint at six months, and we'll start with 28 days of treatment, we'll be off for 56 days of treatment and then 28 days on and 56 days off. After that second treatment cycle will be our primary endpoint, and we are going with a single dose suspension of 80 milligrams inhaled and a 2:1 randomization. We'll have an interim analysis after the first 100 patients and that'll look to make sure that the trial is on track to achieve its endpoint or if we have to make any adjustments based on the statistical plan that's been pre-identified. I want to remind you it's a co-primary endpoint of sputum conversion and patient reported outcomes for the U.S.

and the rest of the world is just sputum conversion. We will conduct one trial with both endpoints for the various countries in the U.S., as well as rest of world. We are currently in Asia right now activating sites, as well as having a kickoff meeting for investigators. I want to thank the team for all the hard work over there.

We do have FDA Fast Track QIDP in orphan, which provides us with 12 years of exclusivity as we get off the ground. Now bridging to nintedanib DPI. This is an exciting opportunity for the company. When we think back, I want to remind you that Technosphere technology is mostly made up of FTKP, plus our Dreamboat device.

And the reason I bring this up is it's a platform technology where we really know where the product flows. And you can go back to some of our earlier studies on radio labeled Technosphere insulin insulation powder, where 90% of the powder is FTKP and about 10% is insulin, and we really see wide distribution across the lungs in the upper and lower lobes. The reason that's important is a lot of people ask, how do we know this drug is going to fly where it needs to? And part of this is based on all the history we have around understanding how FTKP is made, where it flies in the lung and how we bind the excipients through this. And we now have over 5,000 patients taking Tyvaso.

When you think about that those patients have orphan lung disease of pulmonary hypertension, ILD, and I'm sure there are some with comorbidities of IPF and COPD. So now that we have two products approved on the platform, we're very excited to continue to move forward our next one here, which is really MannKind 201. As we know, IPF is a growing therapeutic area with over $4.2 billion in sales in 2022, and this continues to grow each year with the majority of those made up of OFE, which is a great product. It's one of two drugs only approved, but it does have severe GI side effects, which limit patients' ability to stay on the product.

So as we try to think about how do we develop improved products, really, this was the opportunity to lower the systemic exposure while maximizing lung exposure. And we're really happy to see in our Phase 1 study here, which is where we tried three doses, we'll call them cohort A, B -- A1, A2, A3, followed by a multiple ascending dose over seven days where we tested A1 and A2 dosing. We really didn't need to go to A3, but we want to make sure it was safe and tolerable for that data to happen in the future. Overall, this trial was a success.

We saw no dose-limiting toxicities or dose implications on FEV1. And we also saw in our chronic tox study, no significant signals or adverse event findings that would prevent us from moving forward in a chronic administration of this product. So we're really happy to wrap these two things up. We will meet with the FDA on our proposal for further development to move this into a Phase 2/3, hopefully here in 2025.

This is a very exciting time for MannKind as this will be two assets we have going into full-scale clinical trials, which will pave the way for future exponential growth for MannKind. I now want to bridge over to our diabetes business, where we had the first large trial readout this year that we've been investing in over the last couple of years. This trial was designed to really look at usual care, which is inclusive of automated insulin delivery pumps, mainly Tandem and Omnipod in this trial, as well as patients on MDI, comparing that to a single shot of Degludec or Tresiba plus Afrezza. And then, at the end of 17 weeks, these patients were given a second meal challenge and we could see in the first and second meal challenge, significant improvement in postprandial control in the first two hours.

And then, at 17 weeks, everybody went into a single-arm trial at this point and either you rolled over from the Afrezza degludec or you switched to usual care. And what you see here on the next slide is we just released the 30-week data, and I'm really proud to see that the longer you want Afrezza here on the top left, you can see your A1c continue to improve over time. We also continue to see more people getting to goal of almost 42% got to goal, which is unbelievable here and it's a very tough disease in type 1, where the large majority of patients do not sit at goal today. The second part of this study was the readout of those who switched from 17 weeks usual care and what did that happen to them at 30 weeks.

And you can see as clinicians got more experience with Afrezza, we saw an improvement in A1c in those 13 weeks of taking the product, plus we're able to see twice as many people get to goal here on the right side in 13 weeks, which is important as we think about the trial and what Afrezza can do. And I'll remind you, this is people who are already on, they optimize treatments they were taking. They've been with diabetes a long time. And by switching them to Afrezza, we were able to drive more people to goal, which is ultimately a huge benefit to society.

Now let's shift over to our revenues year-to-date. When we look at the EBU profitability has been our focus this year. And when you think about the growth and the transformation we've had, Afrezza grew 16% year over year, while V-Go was slightly down as we shifted to managing V-Go for profitability this year away from volume, and we've been really happy with those outcomes. And then, year-to-date, overall for the business, you can see this year versus last year, it's about a $12 million improvement in bottom-line contribution between managing our expenses, improving our efficiency on COGS and continuing to drive more to the bottom line.

When we look at Q3, we're able to grow Afrezza despite multiple headwinds throughout this year. When we think about what happened earlier this year, we had payers put in double step edits. We had sales force restructuring compounded by a shift in inventory in Q3 as we exited our Walgreens consignment and one of our specialty pharmacies was told to shift patients back out to retail by Optum for all of their patients, not just Afrezza. And a lot of us caused a lot of hiccups here as we went through each quarter through this year, and this is all behind us as we close out Q4.

And this was also followed by a mix of faster growth in four and eight units versus 12, which is a direct reflection of our focus to grow more in the type 1 space versus type 2. So when you look at all that noise, I'll say, going into Q4, we're excited by what we see because so far in the month of October, new prescriptions are up 8% year over year. This is our earliest leading indicator of our success as we look at this quarter and next quarter on how we're going to do. In Q4, we also made a change by removing V-Go from the sales force to double down the focus on Afrezza's growth, and we increased our target incentives around hub referrals and new prescription growth as we exit this year.

Given the outcomes of the INHALE-3 and the upcoming INHALE-1 pediatric results, we expect to continue to shift Afrezza from a profitability mindset to a growth mindset in 2025 and beyond. As we look here, I want to remind you of the pediatric opportunity. There are over 300,000 kids living with type 1 diabetes. This was a 52-week primary study in INHALE-1, ages four to 17, very little were type 2, majority were type 1.

And the primary endpoint is at 6 months. And the data will be coming in here before the end of the year, so we'll be able to update shareholders. And we would expect a pre-NDA filing meeting in the first half. The real issue here is, do we want to try to argue that there should be a six-month filing versus a 12-month filing as the 12-month data will come out roughly late Q2 next year, and the filing would happen after.

If it's a six-month filing, we'll be able to file that earlier in the year. But the FDA has indicated that they expect to want to see the 12-month data before we file. So as we look out, we got INHALE-3 coming with the label change, hopefully on Figure 1, as well as INHALE-1 readout. And we're also you're gonna be seeing an IIT we're funding in gestational diabetes very shortly.

So we continue to look at Afrezza's multitude of growth opportunities in the coming years. And let me stop there and turn it over to Chris to give us an update on our financials.

Christopher B. Prentiss -- Chief Financial Officer

Thanks, Mike, and good afternoon, everyone. I am pleased to discuss our third quarter 2024 financial results. For a summary of our financials, please refer to our press release issued prior to this call and our 10-Q, which is on file with the SEC. As Mike mentioned, our business demonstrated robust double-digit revenue growth compared to last year, led by revenues related to Tyvaso DPI.

Third quarter revenues were $70 million, which represent a 37% increase compared to last year's quarter. For the year-to-date, we recorded revenues of $209 million, a 49% increase over the prior-year period. Looking at the details, Tyvaso DPI royalties contributed $27 million in third quarter revenue, an increase of 34% over the same quarter last year and $75 million or a 48% increase for the nine-month period. On United Therapeutics Q3 earnings call, they noted the revenue growth was due to additional patients and an increase in price.

They also commented that referrals and start patterns remain very robust, reinforcing their confidence in the durability of the growth profile. Collaboration and services revenue was $23 million, a 78% increase from the third quarter of 2023. For the nine-month period, we recorded $74 million, a 108% increase compared to the same period in 2023. The increase over the prior-year period was primarily attributable to increased manufacturing activities for Tyvaso DPI.

Collaboration and services revenue consists primarily of manufacturing revenue based on production activities sold through to UT and the recognition of deferred revenue. In the first half of 2024 and in prior years, we also earned approximately $3 million of revenue related to certain scale-up activities in the first half of 2024, resulting in the expected slight decline in the back half of the year. Afrezza net revenue for the third quarter was $15 million, a 12% increase due to higher demand and improved gross to nets. During the nine-month period, Afrezza revenue was $46 million, a 16% increase over the same period last year.

This increase was due to higher demand, a price increase and improved gross to nets. V-Go net revenue was approximately $5 million for the third quarter, an increase of 5% and the nine-month period was approximately $14 million, a decrease of 6%. This is due to lower product demand, partially offset by improved gross to net adjustments and increased price. Our annual revenue trends from 2020 through the latest 12-month period also show a consistent increase with double-digit revenue growth year over year.

These revenues and our management of the commercial business have led the results on the bottom line. In the third quarter, we recorded GAAP net income of $12 million, which when adjusted for non-GAAP items, results in non-GAAP net income of $15 million. This compares to GAAP net income of $2 million in the prior-year quarter and non-GAAP net income of $4 million. For the nine-month period of 2024, we reported net income of $20 million and non-GAAP net income of $45 million, whereas for the same period in 2023, we reported a net loss of $13 million and a non-GAAP net loss of $1 million.

As we highlighted earlier on the call, last year, we transitioned to running the endocrine business unit for profitability, which has contributed approximately $11 million year-to-date in operating income. This, combined with our net royalty income and the margin earned from collaboration and services has allowed us to fund our two promising development programs to date and also achieved net income of $20 million for the year-to-date period and $45 million non-GAAP. The operational execution of our business, combined with our cash and investments of $268 million as of the end of September, leaves us with a strong balance sheet and the ability to invest in the business for growth. With that, I'll turn the call back over to Mike.

Michael E. Castagna -- Chief Executive Officer and Director

Thank you, Chris. As we look back on 2024, we've executed all of the milestones we've laid out so far with the very last one coming up on INHALE-1, which we fully expect to share with the Street here by the end of the year. We're looking forward to closing out the year. As we look at the first half, we have several key regulatory updates coming around 201 with an end of Phase 1 meeting, Tyvaso DPI and the spray dry expansion, hopefully coming online, 101 continued site activations around the world and patient enrollment and screenings continuing.

We'll also be having discussions with the agency on our INHALE-1 readout and our INHALE-3 data label change as we go forward. The next adventure of the company is extremely exciting as we look at our key value drivers going forward. We have 101 with every 1,000 patients being $100 million in revenue. And as we look out in the NTM space, ARIKAYCE is approaching $400 million in annual sales as we look to 2025, we feel very good that this market helping NTM patients will be a very robust opportunity in the coming years.

201, as we move that one forward, we think this has a real opportunity to help impact the patients' lives impact with IPF who suffer every day from severe diarrhea and GI side effects. As we think about Tyvaso DPI, it's hard for us to control that revenue stream, but we try to give you clarity that we continue to see very strong demand growth in manufacturing opportunities and that for every 10,000 patients here is roughly $300 million to $350 million in revenue to MannKind. With the upcoming readouts next year of TETON 1 and 2, we're gonna be extremely excited about this IPF opportunity, as well as TTOM-TPF, looking forward to continuing to leverage the manufacturing scale that we built up, as well as the opportunity to help a whole another area of patients suffering from IPF. Within the endocrine space, I want to remind you of the pediatrics, every 10% share is roughly $150 million in net revenue.

We feel very comfortable if we can get this indication, we'll be able to achieve a substantial opportunity in children to make their lives hopefully better than what they go through today. The INHALE-3 study we'll be reading out. We're just starting to educate our sales force and customers around this data. And we also will have international expansion updates as we progress throughout 2025.

We're looking forward to bringing all this forward and landing us in a continued growth opportunity in the years to come. We'll have several opportunities to share scientific and investor updates here in Q4, as well as Q1 next year. Starting off with the UBS Global Healthcare Conference next week, we'll be there on Tuesday, followed by an opportunity we invited with Oppenheimer here on December 12th in New York for the Rare Disease Summit. And we'll also be attending the ATTD conference, where we already had several abstracts and presentations accepted around our INHALE-3 data and possible INHALE-1 as we find out more notifications being acceptance.

So we have several opportunities to continue to update you, as well as our key stakeholders in the scientific community around our key data sets in 2025. These are just a few as we start out the year and looking forward to hopefully many more opportunities in 2025 to communicate with you and our other key stakeholders. Thank you very much. We look forward to closing out the year strong and appreciate your continued support.

We'll now open up for Q&A.

Questions & Answers:

Operator

Thank you. [Operator instructions] And our first question will be coming from Andreas Argyrides of Oppenheimer. Your line is open.

Andreas Argyrides -- Analyst

Thanks, operator. Thanks, guys, and congrats on all the progress this quarter. Two questions from us. Regarding 101, can you just give us a sense in thinking about ARIKAYCE and the number that you provided, what percentage penetration that is of the market? And then, where does 101 fit in that and how much bigger can it be? And then, for 201, can you just give us a little bit more detail on the Phase 1 and how that helps inform the Phase 2/3 design, what you may see from an efficacy standpoint? And then, maybe a little bit more detail on the time lines, if we could.

I appreciate that.

Michael E. Castagna -- Chief Executive Officer and Director

Sure. Thank you, Andreas. I think, it came in a little blurry, but I think I heard your first question was on 101 around ARIKAYCE penetration and where does 101 fit in. And as we look at the landscape, I think the first thing is hopefully displacing ARIKAYCE in the refractory population as the administration and hopefully tolerability of 101, if it works efficacy-wise, should sustain the ability to do that very well.

The second area is we are down to a final formulation selection very shortly on 101. And mid- to long term, we also expect to bring a dry powder formulation out that would help penetrate earlier lines of treatment. And so, our ultimate goal is to be used first line and second line or refractory between a dry powder and a nebulizer. Just the nebulizer was the faster way to market.

And so, they're right on top of each other in the grand scheme of things, but that's generally where we expect to be able to compete in early and late lines of treatment in NTM. We'll give further updates in terms of that strategy in a bridging study, or new study, naive study, etc., sometime in '25. The 201 details on how that informs us. I think, the first thing was making sure the chronic tox data was OK because that to me was the first step in this area.

And then, the Phase 1 study was really looking to see what -- if any GI side effects could have occurred? Or was there anything related to OFE type side effects that would give us concern or at least confirming our thesis that they should be minimal, which is what we expected and they were. And then, the second part of that is while they were healthy volunteers, it was the first time we're really putting Nintedanib in a healthy volunteer lung. And we're pretty confident in FTKP, as I stated earlier in the call, but demonstrating that there was no adverse reaction to Nintedanib. We can clearly see in the Phase 1, whether it's the control arm or the, I'll call it, placebo or the active, there was no indicators or any concerns for that.

So that's really shapes us up for the Phase 2. We know the FDA in their preliminary comments wanted a dose range finding study. So that's what we'll go to them with next year. So we are trying to get to either a Phase 2/3 bridge or even just go to our single dose that we want to target and see whether we could down dose if somebody had tolerability issues.

But until we meet with the FDA, I think it's all -- we can't really predict where their heads are gonna be, and we have a good rationale, but whether they agree or disagree is the question. So that's where we are. We expect to get there, hopefully, in Q1, and we'll provide updates as we meet with them.

Andreas Argyrides -- Analyst

Congrats on all the progress.

Operator

And our next question will be coming from Olivia Brayer of Cantor Fitzgerald. Your line is open.

Olivia Brayer -- Analyst

Hey, good afternoon. Thank you for the question. What more can you tell us about MNKD-201's profile just in terms of any differentiation you've seen so far? You guys are, obviously, not the only ones developing an inhaled version of the drug. And did you guys look at PK as it relates to the oral formulation? If so, any comparisons there?

Michael E. Castagna -- Chief Executive Officer and Director

Sure. I think, the -- I think, first of all, we are probably in a speed to move this into patients in a bigger way. And I believe we have the ability to do that in the dry powder formulation in terms of CMC is pretty much ready, as well as our trial design. So it's really just getting this to the FDA.

I think, in terms of one can ask, is there a difference in a nebulizer versus a dry powder. We probably have a little bit of a bias toward dry powder given our company history and background and the success of Tyvaso DPI and what we saw there over their nebulizer. So that's really our -- also our key points of differentiation as we go forward. I think there's always enough room in the market for two players.

So it's really about making a difference in the patients' lives and letting competition compete. But we think that this disease requires hopefully some innovation that we can bring to the marketplace. In terms of the clinical differentiation, as you may or may not realize, these patients take immense amounts ofmodium just to try to stay on OFEV. And that will be some of the stuff we look at is do we reduce the number ofmodium do we reduce diarrhea.

Our proposal to the FDA is a combination of naive and experienced patients. So hopefully, we'll be able to see GI side effect from OFE versus us in that profile. Again, the FDA could change our trial design, and we would focus only on experienced patients potentially. But otherwise, we think the administration is not gonna be the biggest burden in terms of a pill versus inhaled, but the side effect profile of OFEV is really what we're going after.

And hopefully, we can get higher lung concentration. We did measure plasma PK in this trial, not to compare it to OFEV, but just to kind of triangulate to our animal models to see where we were. And that data is still coming in as we speak. So we'll have that full analysis before we go to the FDA.

Olivia Brayer -- Analyst

OK. Understood. And then, just in terms of kind of data disclosure for measuring plasma and PK, is the -- should we expect to see that sometime next year? Or is that something that you'll just go to the FDA with and not necessarily present at a medical meeting or publish?

Michael E. Castagna -- Chief Executive Officer and Director

I don't want to speculate yet because I don't know what the data says relative to our animals and how would we triangulate that or put some information out there. I do think people have been asking around the bleomycin study in this. And so, we'll think about how we can bring some more articulation of our confidence as we go forward and what that trial design looks like and the data behind the support around that. So -- and that's probably the one area I think we're still having some internal discussion on, which is do you do a smaller Phase 2 just to get the efficacy data so people could see that sooner.

And then, that will take a little bit longer of a Phase 2 than a Phase 3, but it would give people more certainty. And so, those are some of the discussions between the FDA and our internal clinical development team.

Operator

And our next question will be coming from the line of Faisal Khurshid of Leerink Partners. Your line is open.

Faisal Khurshid -- Analyst

Hey, guys, thank you for taking the question. I just wanted to ask if you could say a little bit more around the adverse event profile that you saw in the Phase 1 for the inhaled nintedanib. Like with the FEV drop and cough events, could you tell us a little bit more like what's your hypothesis around what caused that? Like is that excipient related? And just anything around like kind of time course of those events? And just any more insight you can give around that?

Michael E. Castagna -- Chief Executive Officer and Director

Yeah. There was no -- I think in the seven-day part, we look to see, did it get worse over the seven days? Did people have it on Day 1, have it on Day 7. The bottom line is there was no real concerns around the drop or the significance of the drop or it didn't continue to get worse. In fact, no one discontinued because of it.

So people that may have got on Day 1, may not have had it on Day 7. Some people didn't have it on Day 1, got on Day 7. So there was no consistency about when or how it appeared. There is one thing I'll highlight for you that I think is important is these patients had to do an FEV1, I think, like every 15 minutes roughly.

So there was like four to five FEV1s in the hour to two hours post dosing. And so, that itself would have a lot of irritation of the lung. And that's something that the FDA wanted. So we did it, but I'm not sure it's going to tell us much.

We'll look at the summary of all that data. But there was a lot of, I'll say, administration of FEV1 throughout the time period of measurement. And so, we are looking at total FEV1 drops from the initial dose all the way through two hours, and that's after repeated FEV1s per patient. So there's a lot of data drawn, a lot to still be summarized, but there was nothing at the highest level when we looked at the data that was of concern or consistency, I'll say.

And it seemed to happen in both the control, as well as the active arm. So there wasn't anything specifically around nintedanib that we would say is also. So I think it's much more around putting dry powder into the lung than anything and the frequency of FEV1 testing that was required.

Faisal Khurshid -- Analyst

Yeah, that sounds like a work out. Just to clarify, the placebo arm was like just a straight excipient without nintedanib. So it's the same kind of dry powder inhalation just with no active drug?

Michael E. Castagna -- Chief Executive Officer and Director

Yeah, FTKP is the excipient.

Operator

Our next question will be coming from the line of Gregory Renza of RBC Capital Markets. Your line is open.

Anish Nikhanj -- Analyst

Hi, Mike and team. It's Anish on for Greg. Congrats on the progress this quarter. Just firstly, on 101, what's the broader value proposition from an economical standpoint for patients and physicians to use MannKind 101 over ARIKAYCE or even oral clofazimine in NTM.

Maybe if you have some early thoughts on where you'd like to land on out-of-pocket cost. And then, Justin keying in on Tyvaso or Tyvaso DPI and the TETON IPF and PPF studies, might 201 also be clinically usable in PPF? I know there's some research out there. Just wanted to get your thoughts.

Michael E. Castagna -- Chief Executive Officer and Director

Yeah, no, thank you. I do think that's -- as we saw another company switched from IPF to PPF. I think, we'll see some results in IPF next year with the TETON 1 and 2. So I think there is an opportunity there, to your point.

Some of that will be we would expect to get, in my mind, extrapolation of indication. So if we look at what nintedanib has indicated for, I think it's really picking the right population with the right trial to get the right endpoint. And I think as part of our request with the FDA, just like we got ILD with Tyvaso DPI, we would hope to get extrapolation with that focus. So that would be our first focus on that.

But to your point, maybe we could go after PPF instead of IPF if we really wanted to. And I think that's still an ongoing discussion, but I think a lot of this is the bigger population of IPF and the predictability of enrollment in that trial. I'll bridge over to your 101 question on the brand value proposition. So I think when you look at clofazimine, it's in all the guidelines, doctors really love it.

Our team is over in Asia right now in Australia activating sites and kicking off the investigator meetings over there. And clofazimine has much more wider use, I'll say, in those markets. And so, the receptivity of our nebulizer form is very high and the belief in clofazimine as a treatment for NTM is very high. And when you think about the couple of side effects of clofazimine, in particular, oral formulation, you're getting skin discoloration, QT prolongation and potentially organ accumulation.

So those are three things you don't want that with the reduced dose in the systemic circulation, but better concentration in the lungs, we would see a better value prop. And then, combine that, I think with ARIKAYCE. ARIKAYCE is an aminoglycoside, so it's got ototoxicity by nature. And I do believe those will be clinically differentiated, especially as you get to infectious disease docs and hospitals who are used to dealing with these things.

I think there'll be a clinical differentiation, potentially a safety. Again, we got to get trial results before we get too excited. But I think conceptually, that's where our heads are. And then, you get to the dosing administration.

Every day, cleaning a device for six months to 18 months of your life is a burden. And that's one of the reasons we chose the dosing we did with clofazimine, which is 28 days on and 56 days off. One is the use of a nebulizer and the PK/PD of the product allows us to probably get that long. And then, the second is the co-pay burden on the patient.

And so, there is no real incentive to the doctors to use, I'll call it, nebulizer or an oral form of a product unlike diabetes where there's an incentive to use an insulin pump that doesn't happen in this disease. But being able to really get that nebulizer down to once a month, which should remain one co-pay to the patient. And so, while the overall WAC cost for month supply will probably be comparable to a three-month supply, I would say that that duration of effect will last you up to three months, and the co-pay will be a one-month thing. And that's important, especially for Medicare, which is generally capped per month as we go into '25.

So that's kind of the value prop on the cost economic side and the dosing and safety that we are thinking about.

Operator

And our next question will be coming from Brandon Folkes of Rodman. Your line is open.

Brandon Folkes -- Analyst

Hi. Thanks for taking my question, and congratulations on the progress during the quarter. I actually want to switch gears and talk a little bit about Afrezza. Can you just talk about the growth in Afrezza and sort of especially the growth in terms of the breadth and depth of prescribers? And what is the unaided awareness out there in the market just in the investment that MannKind has put into Afrezza data over the last year.

Is there some level of anticipation of that data among your current prescribing community? And then, how do we see the Afrezza commercial footprint evolving over time just given that backdrop, especially as we sort of move into the pediatric label and then sort of really make a move on the inhaled data?

Michael E. Castagna -- Chief Executive Officer and Director

Thank you, Brandon. Nice to hear from you. There's a few questions wrapped up in there. And so, I would say, the unaided awareness of Afrezza among doctors is what we'd expect given the investment in our narrow target, meaning we target probably about 4,000 to 5,000 docs in any given quarter.

And the number that actually write on a consistent basis is, obviously, much less. And so, that gets you to our focus, which is not broadening prescribers right now. It's actually going deeper with the current prescribers who've used the product because we got to a point this year where we really reduced our sales force from roughly 80 people down to 50. And so, with that 40% cut, we had to go narrow and deep.

And that strategy seems to be working. We're seeing growth within our targets that we're really on top of. And we've seen that we've lost a little bit of scripts in the non-targets, I'll say, or in some of those docs that we had to leave with the reduction in the sales force. But the hope was we would make up that drop on those that we are targeting.

So that does appear to be kind of making that transition as we got from Q2 to Q3 to early Q4. The other part that we are seeing in the endocrine space, and you can kind of see the insulin scripts, I think the overall TRx has dropped roughly 3% to 5% in Q3 in the overall rapid-acting mealtime market. And Afrezza, obviously, dropped from Q2 to Q3 a little bit. And some of that is we are seeing the endos switch from treating diabetes to actually treating weight loss.

And they're just literally wholesale shifting their focus and their patient volumes. And so, we'll see how that continues to play out. I don't expect it to impact Afrezza in a dramatic way because we have more than enough prescribers that we still need to help and work on. But that was some of our top prescribers.

We start to see, and that's why it is important to broaden our commercial focus beyond the ones that we do have. And overall, as we go forward, we want to kind of see the reaction to the INHALE-3 data. So that came out -- the 30-week data just came out a few weeks ago here. And that data will be published in a reputable journal probably in the next four to eight weeks.

And so, that's been accepted. And then, we have a bunch of presentations at ATTD, and we're just starting to educate the marketplace. So we'll be looking to bring MSLs out in 2025 to really start to get into the academic centers and fellowship trainings and really focus a little bit more on getting out from underneath the burden, I'll say, of the safety perceptions of inhaled insulin and how we start to put that on the table and move forward on the efficacy opportunities to help more patients. So it's a lot in your question, but I do think we got a good grasp of what's going on, and we feel pretty good about the direction we are going and our ability or desire to shift investment to grow it faster, at least put some resources behind key areas to make a difference.

Brandon Folkes -- Analyst

And congratulations again.

Operator

And this does conclude the Q&A session for today. I would like to turn the call back over to management for closing remarks. Please go ahead.

Michael E. Castagna -- Chief Executive Officer and Director

Thank you, Lisa, for moderating today, and thank you to all the MannKind team and our shareholders. We've had a great year so far. We're going to close the year strong and looking really forward to 2025, and we'll continue to give you guys updates as things come in. But there's, obviously, a lot going on, all in a great way, and we look forward to continue to open up that communication line and feel free to reach out with any questions.

Thank you.

Operator

[Operator signoff]

Duration: 0 minutes

Call participants:

Michael E. Castagna -- Chief Executive Officer and Director

Christopher B. Prentiss -- Chief Financial Officer

Mike Castagna -- Chief Executive Officer and Director

Andreas Argyrides -- Analyst

Olivia Brayer -- Analyst

Faisal Khurshid -- Analyst

Anish Nikhanj -- Analyst

Brandon Folkes -- Analyst

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MannKind (MNKD) Q3 2024 Earnings Call Transcript was originally published by The Motley Fool