ImmunOs Therapeutics Raises $74 Million Series B Financing Round

- New investors Samsara, Lightspeed, Gimv, and Mission BioCapital further strengthen investor base and expand transatlantic footprint

- Company establishes U.S. subsidiary to accelerate international operations

Schlieren (Zurich Area), Switzerland, and Gaithersburg, MD, USA – June 7, 2022 – ImmunOs Therapeutics AG, a biopharmaceutical company leveraging its HLA-based technology platform to develop first-in-class therapeutics for the treatment of cancer and autoimmune diseases, today announced the closing of an oversubscribed Series B financing round totaling $74 million. The round was led by new investors Samsara BioCapital, Lightspeed Venture Partners, and Gimv, and joined by new investors Mission BioCapital, GL Capital, PEAK6 Strategic Capital, and Fiscus Financial, as well as existing investors Pfizer Ventures, BioMed Partners, and Schroder Adveq. In connection with the financing, Shelley Chu, MD, PhD, Partner at Lightspeed, Marcos Milla, PhD, Venture Partner at Samsara, and Andreas Jurgeit, PhD, Partner at Gimv, will join the Company’s Board of Directors, which currently includes Reinhard Ambros, PhD, Chairperson and former Head of the Novartis Venture Fund, Daniel Vasella, MD, Vice Chairperson and former Chairperson and CEO of Novartis AG, Markus Hosang, PhD, General Partner at BioMed Partners, Michael Baran, PhD, Partner at Pfizer Ventures, and Sean R. Smith, CEO of ImmunOs.

The proceeds of the Series B will be used to fund the clinical development of ImmunOs’ lead program, IOS-1002 (formerly iosH2), through Phase 2 clinical trials and to progress additional oncology and autoimmune disease programs within the Company´s HLA-based pipeline towards clinical development. IOS-1002 is a first-in-class, multi-functional agent based on a naturally occurring human leukocyte antigen (HLA) that targets key components of the innate immune system, including LILRB1 (ILT2), LILRB2 (ILT4), and KIR3DL1, and synergizes with the adaptive immune system, thereby leading to profound anti-tumor activity. A Phase 1 clinical trial is planned to start in the second half of 2022.

Additionally, ImmunOs has established a U.S. subsidiary to further expand its international reach, execute future U.S. clinical trials, and strengthen its transatlantic operations and team.

"We are delighted to close this significant financing round led by a group of top-tier U.S. and European investors," said Sean R. Smith, CEO of ImmunOs Therapeutics. "The raise underlines our promising, first-in-class immunotherapy approach for the treatment of both solid and liquid tumors. The funding allows us to advance our lead program, IOS-1002, into clinical trials, expand our pipeline in oncology and autoimmune disease, and strengthen our transatlantic operations. We are honored that renowned investors such as Samsara, Lightspeed, Gimv, Mission BioCapital, GL Capital, PEAK6, and Fiscus have joined our investor base."