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We have hired highly capable and experienced leaders, including Dr. Edwin Rock as Chief Medical Officer; Deepak Kuvari as Vice President of Technical Operations; Bruce Johnson as Chief Commercial Officer; and most recently, Chinmaya Rath as our new Chief Business Officer. Ed provides critical oversight, strategic guidance and regulatory insight as we advance through the late stages of clinical development. While Chinmaya applies his expertise from over two decades as biotech and pharmaceutical companies to oversee our corporate strategy and early stage pipeline programs. In parallel, Bruce and his team remain hard at work educating the market on uproleselan's differentiated mechanism of action, driving awareness of the unmet medical needs in the relapsed/refractory AML and leading key commercial readiness activities to ensure we are well positioned to deliver uproleselan, if approved, to patients in need.

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Deepak and his team continue planning and preparing for commercial supply following recent completion of the API validation batches of uproleselan. Turning to our second key focus area, the execution of our pivotal Phase III study of uproleselan in relapsed/refractory AML. In this study, patients continue to live longer than expected, leading to a median follow up prior to primary analysis in our study that is currently greater than 25 months, which is remarkable. As a reminder, the final survival event trigger based on projections that reflect this longer follow up duration is currently expected to occur in the first half of 2024. Last fall, based on slower accumulation of survival events, we recognized an ethical need to address the possibility that this slowdown in survival events may relate to benefit from uproleselan study therapy.

Following consultation with medical experts on the blinded pool data, we aligned with the FDA to establish an interim utility analysis in our Phase III study protocol at approximately 80% of the planned survival events. In preparation for this interim analysis, our team partnered with the clinical trial community to ensure thorough data cleaning ahead of the final database lock. The interim analysis, which employed a very high statistical threshold in order to preserve the statistical integrity of the originally planned final overall survival analysis was conducted in February of this year 2023. The independent data monitoring committee recommended we continue to the originally planned final analysis while noting there were no safety concerns.

Later in the call, Ed will provide additional context on the high threshold used at interim analysis and how this preserves statistical integrity for the final analysis. As noted earlier, median follow-up for our study of uproleselan is currently greater than 25 months. Given this extended median follow-up duration, we have assessed other relapsed/refractory AML studies for the time from randomization to primary analysis. To our knowledge, as our study continues to mature, it is on track to have the longest follow-up of any study in relapsed/refractory AML at the point of primary analysis at potentially more than three years. We are encouraged by this continued demonstration of uproleselan's safety profile and remain optimistic about uproleselan's potential in light of the extended median follow-up duration in our study and the fact that patients continue to live longer than previously expected.

Finally, we're pleased to announce in February that we completed a $32.9 million financing, which is expected to extend our cash runway to the end of 2024. We're encouraged by the support we received from a science driven investor base, recognizing the potential of our Phase III study and clinical programs. This funding ensures our organization is well positioned to continue advancing our pivotal Phase III study of uproleselan in relapsed/refractory AML. On today's call, I'm pleased to be joined by our CFO, Brian Hahn; and CMO, Dr. Ed Rock. Ed, I'll pass it over to you to share more detail on the interim analysis and other recent study developments.

Edwin Rock: Thanks, Harout, and thanks to everyone for joining our call today. As Harout mentioned, we remain encouraged by the recently completed interim utility analysis of our Phase III trial of uproleselan for relapsed and refractory AML. Interim analysis sought to assess whether the prolonged survival follow up that we have been observing could be due to uproleselan benefit in this population. With FDA concurrence, we designed interim analysis to use a conservative modified obrine flemming method to generate a high statistical threshold for stopping the study early. This high bar to an early stop had two intended outcomes. First, the positive result based on 80% of planned survival events would by itself represent compelling evidence of uproleselan benefit.

Second, if the study was to continue then about 95% of the study's statistical significance, also known as ALFA, would be preserved for the subsequent final survival analysis of the primary endpoint. As mentioned, implementation of the interim analysis gave GlycoMimetics wto shots on goal with the uproleselan study. Keep in mind, those two shots were not designed equally as the interim analysis used roughly 120th or about 5% of available ALFA and the final analysis is planned to use the rest, about 95% of total available ALFA for the study. So these two shots on goal are aiming at different targets with about 5% of ALFA used to target for interim analysis was very small. Conversely, as the trial matures toward final analysis, the statistical boundary aligns much more closely to the original analysis designed as part of the original study protocol.

The key takeaway here is that uproleselan remains a first in class drug candidate with potential broad utility, a clean safety profile and the possibility to demonstrate survival prolongation in patients with AML. Blinded pooled data show that the transplant rate in the study is above the 31% transplantation rate observed in the preceding Phase I/II trial. Additionally, we observed a patient dropout rate of about 3%. This low dropout rate gives us confidence that loss to follow up is not contributing to slow event accumulation in the trial. Rather, our biologic hypothesis is that uproleselan study treatment leads to deeper, more durable AML disease remissions that could help bridge more patients to and through stem cell transplantation, possibly resulting in improved overall survival.

In summary, this study population continues to live longer than expected based on historical benchmarks seen in other relapsed and refractory AML studies. To our knowledge, this trial remains on track to have the longest follow up of any study in relapsed and refractory AML at its time of primary analysis, now at potentially more than three years. We look forward to providing our final overall survival analysis shortly after reaching the final survival events trigger currently projected to occur in the first half of 2024. In addition, we continue to monitor primary event accumulation closely. At GlycoMimetics, we remain focused on delivering new options to patients who continue waiting for a new and better standard of care therapy for this highly lethal disease.

Now I'll hand over to Brian for an overview of financial results.

Brian Hahn: Thank you, Ed. As of December 31, 2022, GlycoMimetics had cash and cash equivalents of $47.9 million as compared to $90.3 million as of December 31, 2021. Expenses for the second half of 2022 decreased to $19.2 million as compared to over the first half of 2022. From the fourth quarter of 2022 until February 2023, we sold 11,776,784 shares of common stock under our existing at the market sales facility, raising a total of $32.9 million in net proceeds. These additional proceeds are expected to extend our cash runway to the end of . We intend to use our capital resources to advance the clinical development of and prepare regulatory filings for marketing approval of uproleselan and the plan for uproleselan's potential commercialization to continue the evolution of GlycoMimetics into a commercial stage company.

Company's research and development expenses decreased to $5.9 million for the quarter ended December 31, 2022 as compared to $12.9 million for the same period in 2021. Decreased expenses were primarily due to the lower global Phase III clinical study and development costs as patient enrollment ended in November 2021. The company's general and administrative expenses increased to $4.7 million for the quarter ended December 31, 2022 as compared to $4.5 million for the fourth quarter of 2021, primarily due to higher pre-commercial expenses for uproleselan in 2022, offset by lower grant date fair market value for equity awards issued in 2022. I'd now like to turn the call back to Harout.

Harout Semerjian: Thank you, Brian. This is a very exciting time for GlycoMimetics. We're encouraged that the recent interim analysis of our Phase III study found no safety concerns with uproleseran treatment, and the study was recommended to continue the final analysis. Patients in this study continue to live longer than expected and to our knowledge, it is on track to have the longest follow up of any study in relapsed/refractory AML at the point of primary analysis at potentially more than three years. With our recent $33 million financing, we are well positioned to continue the study to its final events trigger expected to occur in the first half of 2024. And we look forward to sharing updates with you on future calls as we work to become a commercial stage company capable of delivering important new medicines to patients who need them most. I'd now like to open the lines to Q&A. Operator?

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