Global Targeted Protein Degradation Market (2021 to 2030) - by Type of Protein Degrader, Therapeutic Areas, Route of Administration, Key Contributing Technologies and Key Geographies
Targeted protein degradation is a revolutionary pharmacological concept that presents viable drug development opportunities and is anticipated to introduce a new paradigm in modern therapeutic interventions. Due to various reasons, conventional drugs / therapies have been limited in terms of their capability to target certain proteins of pathological significance. Presently, medical researchers engaged in the development of bifunctional protein degrader-based interventions claim that this upcoming class of drugs is capable of targeting biomolecules in the human proteome, which were previously considered undruggable. The concept of targeted protein degradation revolves around the use of small molecule leads, which are capable of recruiting the ubiquitin-proteasome system (UPS) to selectively eliminate a target biomolecule.
In other words, protein degraders regulate biological pathways by selectively downregulating a target protein by degrading them; this process has been shown to be robust, more sensitive to drug-resistant targets and can regulate cellular functions that are not dependent on enzyme action. Moreover, drugs designed based on this relatively novel concept, have been shown to demonstrate a remarkable level of selectivity, high potency, oral bioavailability and differentiated pharmacology, compared to traditional enzyme inhibitors. As a result, this upcoming class of drugs has garnered significant interest within the medical science community. In fact, the growing popularity of targeted protein degradation is evident in the USD 5 billion in capital investments made into companies engaged in this field of research, since 2014.
Proteolysis targeting chimera (PROTAC), developed by Hashimoto Laboratory in 2008, was the first targeted protein degrader. The incessant efforts of researchers involved in this domain have resulted in significant progress towards understanding the physiochemical and biological properties of such bifunctional molecules. Presently, there are several other types of targeted protein degraders and molecular glues, which have been / are being developed for the treatment of a variety of clinical conditions, including acute myeloid leukemia, Alzheimer's disease, breast cancer, myelofibrosis, multiple myeloma, Parkinson's disease, prostate cancer, psoriasis, rheumatoid arthritis, and supranuclear palsy. It is worth noting that the R&D efforts in this field are supported by DNA-encoded libraries and other in silico hit discovery and characterization tools. In the last 4-5 years, there has been a marked rise in the number of new entrants in this market.
Additionally, several big pharma players are also actively involved in this field, evaluating proprietary protein degrader-based therapeutic leads. The market has also witnessed substantial partnership activity over the last few years, with several technology developers involved in high-value licensing deals. Although, there are no approved protein degrader-based drugs / therapy products, the market is poised to witness healthy growth over the next decade.
Amongst other elements, the report includes:
A detailed review of the current market landscape of targeted protein degradation-based therapeutics, including information on type of protein degrader (degronimids, ENDTACs, epichaperome inhibitors, hydrophobic tags, IMiDs, LYTACs, molecular glues, PHOTACs, PROTACs, protein homeostatic modulators, SARDs, SERDs, SNIPERs, and specific BET and DUB inhibitors), phase of development (clinical, preclinical, and discovery stage) of product candidates, target indication(s), key therapeutic area(s), type of biological target(s), associated ubiquitin ligase(s) (if available), target signaling pathway (if available), mechanism of action (if available), type of therapy (monotherapy and combination therapy), route of administration (oral, intravenous and others). In addition, it presents a list on drug / therapy developer(s) (such as year of establishment, company size and location of headquarters), clinical study sponsor(s) and collaborator(s).
An overview of the overall landscape of target protein degradation enabling technologies, featuring an analysis based on type of degrader. In addition, it presents a list of targeted protein degradation enabling technology developers and analysis based on various parameters, such as year of establishment, company size and location of headquarters.
Detailed profiles of prominent players engaged in the development of targeted protein degraders (shortlisted on the basis of phase of development of pipeline products). Each profile features a brief overview of the company, its financial information (if available), detailed description of their respective lead drug candidates, and recent developments and an informed future outlook. Additionally, each drug profile features information on the type of drug, current status of development, route of administration, target indications, and a brief summary of its developmental history.
Tabulated profiles of leading industry players (shortlisted on the basis of the number of candidates in development pipeline). Each profile includes details on the innovator company (such as year of establishment, location of headquarters, number of employees, and key members of the executive team), recent developments, along with information on respective drug candidates.
An in-depth analysis of completed, ongoing and planned studies of various targeted protein degraders, highlighting prevalent trends across various relevant parameters, such as current trial status, trial registration year, enrolled patient population and regional distribution of trials, type of protein degrader, phase of development, study design, leading industry and non-industry players (in terms of number of trials conducted), trial focus, target therapeutic area, key indications, and clinical endpoints.
A detailed analysis of grants that have been awarded to various research institutes for targeted protein degradation projects, in the period between 2017 and 2020, on the basis of important parameters, such as year of award, amount awarded, administering institute center, support period, funding mechanism, type of grant application, purpose of grant award, activity code, emerging focus areas of the grants, study section, popular NIH departments, study section, and type of recipient organization, highlighting popular recipient organizations, popular program officers and regional distribution of recipient organizations.
A detailed publication analysis peer-reviewed, scientific articles that have been published between 2017 and Q3 2019, highlighting the research focus within the industry. It also highlights the key trends observed across publications, including information on type of publication, year of publication, study objective, popular keywords, type of protein degrader, biological target, associated ubiquitin enzyme, number of publications, type of publisher, leading players (in terms of number of publications), region, and key journals (in terms of number of articles published in this domain and impact factor of the journal).
An insightful analysis of the patents filed / granted for targeted protein degradation enabling technologies, since 2018, taking into consideration various parameters, such as type of patent, publication year, geographical location, type of applicant, issuing authority / patent offices involved, CPC symbols, emerging focus areas, leading players (in terms of number of patents granted / filed in the given time period), patent characteristics and geography. The chapter also includes a detailed patent benchmarking and an insightful valuation analysis.
A list of key opinion leaders (KOLs) within this domain, and their assessment (based on the strength and activeness) represented in the form of 22 matrices. The chapter also includes a schematic world map representation (highlighting the geographical locations of eminent scientists / researchers) and an analysis evaluating the (relative) level of expertise of different KOLs, based on number of publications, number of citations, participation in clinical trials, number of affiliations and strength of professional network (based on information available on ResearchGate).
An analysis of the partnerships that have been established in this domain, during the period 2014-2020, covering research agreements, product / technology licensing agreements, mergers / acquisitions, asset purchase agreements, R&D and commercialization agreements, IP licensing agreements, clinical trial agreements, product development agreements, and other relevant deals.
Key Questions Answered
Who are the leading industry and non-industry players engaged in this market?
What are the key therapeutic areas for which target protein degraders are being / have been developed?
Which geographies are the most active in conducting clinical trials on target protein degraders?
What kind of partnership models are commonly adopted by industry stakeholders?
Which are the leading administering institute centers supporting the research related to this domain?
What is the trend of capital investments in the targeted protein degradation market?
How has the intellectual property landscape in this market evolved over the years?
How is the current and future market opportunity likely to be distributed across key market segments
Key Topics Covered:
1. PREFACE
2. EXECUTIVE SUMMARY
3. INTRODUCTION
4. CURRENT MARKET LANDSCAPE: TARGET PROTEIN DEGRADATION-BASED THERAPEUTICS 4.1. Chapter Overview 4.2. Targeted Protein Degradation-based Therapeutics: Development Pipeline 4.2.1. Analysis by Type of Protein Degrader 4.2.2. Analysis by Phase of Development 4.2.3. Analysis by Therapeutic Area 4.2.4. Analysis by Target Indication 4.2.5. Analysis by Biological Target 4.2.6. Analysis by Associated Ubiquitin Ligase 4.2.7. Analysis by Type of Therapy 4.2.8. Analysis by Route of Administration 4.3. Targeted Protein Degradation-based Therapeutics: Developer Landscape 4.3.1. Analysis by Year of Establishment 4.3.2. Analysis by Company Size 4.3.3. Analysis by Type of Protein Degrader 4.3.4. Analysis by Location of Headquarters 4.3.5. Leading Players: Analysis by Number of Drug Candidates
5. CURRENT MARKET LANDSCAPE: TARGET PROTEIN DEGRADATION ENABLING TECHNOLOGIES 5.1. Chapter Overview 5.2. Targeted Protein Degradation Enabling Technologies: List of Research Tools / Key Technology Platforms 5.2.1. Analysis by Type of Protein Degrader 5.2.2. Analysis by Number of Drugs under Development 5.3. Targeted Protein Degradation Enabling Technologies: Developer Landscape 5.3.1. Analysis by Year of Establishment 5.3.2. Analysis by Company Size 5.3.3. Analysis by Location of Headquarters
6. COMPANY PROFILES 6.1. Chapter Overview 6.2. Developers with Late-stage Clinical Candidates 6.2.1. Radius Health 6.2.1.1. Company Overview 6.2.1.2. Financial Information 6.2.1.3. Targeted Protein Degradation-based Product Portfolio 6.2.1.3.1. Elacestrant (RAD1901) 6.2.1.4. Recent Developments and Future Outlook 6.2.2. Celgene 6.2.2.1. Company Overview 6.2.2.2. Financial Information 6.2.2.3. Targeted Protein Degradation-based Drug Portfolio 6.2.2.3.1. Avadomide (CC-122) 6.2.2.3.2. Iberdomide (CC-220) 6.2.2.4. Recent Developments and Future Outlook 6.2.3. Sanofi Genzyme 6.2.3.1. Company Overview 6.2.3.2. Financial Information 6.2.3.3. Targeted Protein Degradation-based Drug Portfolio 6.2.3.3.1. SAR439869 6.2.3.4. Recent Developments and Future Outlook 6.2.4. AstraZeneca 6.2.4.1. Company Overview 6.2.4.2. Financial Information 6.2.4.3. Targeted Protein Degradation-based Drug Portfolio 6.2.4.3.1. AZD9833 6.2.4.4. Recent Developments and Future Outlook 6.3. Developers with Preclinical / Early-stage Clinical Candidates 6.3.1. Arvinas 6.3.2. BioTheryX 6.3.3. Captor Therapeutics 6.3.4. C4 Therapeutics 6.3.5. Genentech 6.3.6. Hinova Pharmaceuticals 6.3.7. Kangpu Biopharmaceuticals 6.3.8. Kymera Therapeutics 6.3.9. Mission Therapeutics 6.3.10. Progenra 6.3.11. Zenopharm
7. CLINICAL TRIAL ANALYSIS
8. ACADEMIC GRANTS ANALYSIS
9. PUBLICATION ANALYSIS
10. PATENT ANALYSIS
11. KOL ANALYSIS
12. PARTNERSHIPS AND COLLABORATIONS
13. FUNDING AND INVESTMENT ANALYSIS
14. MARKET SIZING AND OPPORTUNITY ANALYSIS
15. LICENSING DEAL STRUCTURE
16. EXECUTIVE INSIGHTS
17. CONCLUDING REMARKS
18. APPENDIX 1: TABULATED DATA
19. APPENDIX 2: LIST OF COMPANIES AND ORGANIZATIONS
