In This Article:
Data from the BEXMAB study marks a significant milestone for next-generation cancer immunotherapies
TURKU, FI / ACCESS Newswire / April 24, 2025 / Faron Pharmaceuticals Ltd. (AIM:FARN), a clinical-stage biopharmaceutical company developing novel immunotherapies, announces that new Phase II data from its ongoing BEXMAB study evaluating bexmarilimab in high-risk myelodysplastic syndromes (HR-MDS) will be presented as a part of a Rapid Oral Abstract Session at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place from 30 May to 3 June 2025, in Chicago, Illinois, USA.
The abstract, selected for oral communication, highlights the efficacy and tolerability of bexmarilimab , Faron's novel humanized anti-Clever-1 antibody, with no dose-limiting toxicities during dose escalation, when used in combination with standard-of-care, azacitidine, treatment in patients with both treatment naïve (frontline) and relapsed/refractory (r/r) HR MDS patients.
"We are thrilled to see bexmarilimab's potential continuing to translate into clinical benefit for patients with this challenging hematologic malignancy," said Dr. Petri Bono, Chief Medical Officer of Faron Pharmaceuticals. "The Phase II results build on our understanding of Clever-1 biology and bexmarilimab's mode of action, and we believe this novel immunotherapy could offer a meaningful new treatment pathway for patients. The acceptance of our results for an oral presentation also represents an important company milestone, as it reflects the scientific interest we have generated, as recognized by the largest global oncology community - ASCO "
Faron's presence at ASCO 2025 reinforces the Company's commitment to advancing science-driven novel immunotherapy solutions and to addressing unmet medical needs in oncology.
The details of the oral presentation are as follows:
| Presentation title | Efficacy of macrophage checkpoint Clever-1 inhibition with bexmarilimab plus azacitidine in myelodysplastic syndrome: Results from the ph1/2 BEXMAB study. |
| Session type and title | Rapid Oral Abstract - Hematologic Malignancies - Leukemia, Myelodysplastic Syndromes, and Allotransplant |
| Session date | 30 May 2025 |
| Time | 1:00 PM - 2:30 PM CDT |
| Abstract no | 6513 |
| Presenter | Dr. Naval Daver, MD | Department of Leukemia, The University of Texas MD Anderson Cancer Center |
For more information, please contact:
| IR Partners, Finland |
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| FINN Partners, US |
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| Cairn Financial Advisers LLP |
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| Sisu Partners Oy |
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About BEXMAB
The BEXMAB study is an open-label Phase I/II clinical trial investigating bexmarilimab in combination with standard of care (SoC) in the aggressive hematological malignancies of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). The primary objective is to determine the safety and tolerability of bexmarilimab in combination with SoC (azacitidine) treatment. Directly targeting Clever-1 could limit the replication capacity of cancer cells, increase antigen presentation, ignite an immune response, and allow current treatments to be more effective. Clever-1 is highly expressed in both AML and MDS and associated with therapy resistance, limited T cell activation and poor outcomes.