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Press Release
October 1, 2018
Significant benefits from ColdZyme in a major German multicenter study evaluating different common cold symptom scales
Preliminary analysis of the Enzy-003 study on naturally occuring common cold, shows a significant reduction of disease duration and symptoms with ColdZyme usage, and less use of concomitant symptom-relieving self-medications, compared to a control group without ColdZyme intervention. In this single-blinded, prospective, and controlled multicenter study, which was conducted at six German sites during the cold season 2018, 400 participants were enrolled and randomized to either start with ColdZyme throat spray at first symptoms of common cold, or no treatment. In total 269 participants with confirmed common cold were included and evaluated in the study.
The Enzy-003 was an exploratory study designed to investigate the ability of the Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21 Quality of life scale), the Jackson score for common cold, and two different sore throat scales, to detect a beneficial effect of ColdZyme compared to a group not treated with ColdZyme. In addition, safety data and the use of concomitant symptom-relieving self-medication were recorded.
All four symptom scales demonstrated an ability to detect a statistically significant benefit from the usage of ColdZyme compared to no intervention, most sensitive being the WURSS-21 functional parameters. Moreover, the use of concomitant symptom-relieving medications against common cold was significantly lower with ColdZyme users. The study also showed no difference in side effects between the two patient groups.
"The consistently positive results with ColdZyme in the actual study strongly indicate that ColdZyme both relieves and shortens the common cold, and reduces the need of symptom relieving medications. Further, the results support large observational studies previously conducted with ColdZyme demonstrating its positive effects. The results will provide a strong foundation to continue strengthening the brand and the claim portfolio within our clinical trial program," says Fredrik Lindberg, CEO at Enzymatica.
ColdZyme, being one of few treatments that addresses the source of common cold by protecting the mouth and throat from virus attachment, has in a few years established itself as one of the best-selling common cold products in Swedish pharmacies. Today the product is sold in Sweden, Denmark, Norway, Finland, Iceland, UK, Spain, and Greece, and through the collaboration partner STADA in Germany, Belgium and Austria. The company is in negotiations with a number of potential distributors for the launch of ColdZyme in other markets.