Disclosure under Chapter 9, Section 5 of the Finnish Securities Markets Act

BIOTIE THERAPIES CORP. STOCK EXCHANGE RELEASE December 14, 2015 at 3.10 p.m.

Disclosure under Chapter 9, Section 5 of the Finnish Securities Markets Act

Biotie Therapies Corp. (Nasdaq Helsinki BTH1V; NASDAQ: BITI) ("Biotie" or the "Company") has on December 12, 2015 received a notification in accordance with Chapter 9, Section 5 of the Finnish Securities Markets Act from Versant Ventures V, LLC on behalf of itself and Versant Venture Capital V, L.P. as a result of the implementation of changes to the transparency directive in the Finnish Securities Market Act.

According to the notification, the total number of Biotie shares owned directly or through financial instruments by Versant Ventures V, LLC and its funds was 8.80 per cent of Biotie`s total number of shares and voting rights on 26 November 2015. Biotie`s registered total number of shares and voting rights amounting to 1,086,940,271 has been used in the calculation of percentages for the announcement.

Total positions of Versant Ventures V, LLC and its funds subject to the notification:

% of shares and voting rights (total of A)

% of shares and voting rights through financial instruments (total of B)

Total of both in % (A + B)

Resulting situation on the date on which threshold was crossed or reached

5.39

3.41

8.80

Position of previous notification (if applicable)

5.97

N/A

N/A

Notified details of the resulting situation on the date on which the threshold was crossed or reached:

A: Shares and voting rights

Class/type of shares
ISIN code (if possible)

Number of shares and voting rights

% of shares and voting rights

Direct
(SMA 9:5)

Indirect
(SMA 9:6 and 9:7)

Direct
(SMA 9:5)

Indirect
(SMA 9:6 and 9:7)

Shares
(FI0009011571)

-

37,051,651

-

3.41

Shares
(FI0009011571)
represented by
268,672 ADSs

-

21,493,760

-

1.98

SUBTOTAL A

58,545,411

5.39

For further information on the ADSs representing the Company`s shares, the notification refers to the stock exchange release issued by the Company on June 11, 2015.

B: Financial instruments according to SMA 9:6a

Type of financial instrument

Expiration date

Exercise/
Conversion period

Physical or cash settlement

Number of shares and voting rights

% of shares and voting rights

Warrants entitling to shares (new or treasury shares) (FI0009011571)

Nov 1, 2020

Nov 1, 2015 - Nov 1, 2020

Physical settlement

37,051,651

3.41

SUBTOTAL B

37,051,651

3.41

For further information on the warrants, the notification refers to the stock exchange release issued by the Company on April 23, 2015.