The CNN presidential debate descended into an epic, no-holds-barred brawl

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(AP Photo/Mark J. Terrill)
Donald Trump.

Donald Trump didn't wait long to lay into Republican presidential rival Sen. Rand Paul of Kentucky during Wednesday night's prime-time Republican debate.

"First of all, Rand Paul shouldn't even be on the debate stage," Trump said in response to an unrelated question about his temperament in one of the first exchanges of the night.

"He's No. 11," Trump continued. "He's got 1% in the polls. And how he got up here, there's far too many people anyway. And we all know that. As far as temperament, I think I have a great temperament."

From the opening bell Wednesday night, the second official Republican presidential debate between the major candidates was a nasty, insult-filled affair.

CNN moderators constantly urged the various White House hopefuls to respond to the mean and insulting things said about them.

That included past trash talk about the candidates' spouses, business records, physical appearance, policy issues, and more. Much of this centered on Trump, the brash real-estate mogul who is the Republican front-runner.

Needless to say, the candidates obliged.

Trump started things off by questioning the right of Paul to even be on the 11-person stage. Paul responded by saying Trump's attack didn't have anything to do with the matter at hand. And he was one of the few candidates to say he was "concerned" about having Trump in charge of the country's nuclear arsenal, citing what he described as Trump's penchant to overreact to criticism.

He alluded to Trump's recent apparent mocking of presidential rival Carly Fiorina's appearance.

"I kind of have to laugh," Paul said. "I'm very concerned about having him in charge of the nuclear weapons because I think his visceral response to attack people on their appearance — short, tall, fat, ugly — my goodness, that happened in junior high. Are we not way above that? Would we not all be worried to have someone like that in charge of the nuclear arsenal?"

Trump responded by delivering a burn against Paul's looks: "I never attacked him on his looks and believe me: There is plenty of subject matter right there."

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(AP Photo/Chris Carlson)
The Republican candidates at the CNN debate Wednesday night.

But the fireworks didn't end there. In fact, they were only beginning.

Trump and Jeb Bush shared many notable exchanges, including shortly after the real-estate developer's tiff with Paul. CNN asked Bush to respond to Trump's claim that Bush, the former Florida governor, was beholden to the special-interest donors who have funneled millions of dollars into Bush's super PAC.