President Joe Biden signed more than a dozen executive orders just hours after entering the White House, including several to address the federal government’s response to the coronavirus pandemic.

“We are entering what may be the toughest and deadliest period of this virus,” Biden said during his inauguration speech.

Biden signed a mask mandate that would apply to all federal buildings, employees, plus certain federal lands and modes of transportation, according to press secretary Jen Psaki at her first briefing Wednesday evening.

He also launched a 100-day mask challenge to encourage all Americans to wear masks and help curb the spread of the virus — stopping short of a federal mandate. The move is increasingly important as health experts are now focused on the potential for the U.K. variant, know as B.1.1.7, to cause another surge by March.

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases (NIAID), will participate in the World Health Organization (WHO) meeting on Thursday as the head of the U.S. delegation, according to Psaki.

The move is a reversal from the Trump administration, which sought to exit from the international agency amid the pandemic.

Biden has also appointed a COVID-19 Response Coordinator and team to help coordinate efforts such as the production and distribution of protective gear, vaccine supplies and distribution. The team will also help states with their own COVID-19 efforts.

The National Security Council team responsible for global health security and biodefense has also been re-established.

Psaki noted the president intends to hold another briefing Thursday to include more details of the administration’s efforts to combat the pandemic. Psaki said Biden “remains committed to invoking the Defense Production Act,” and will discuss that on Thursday.

The vaccine problem

Meanwhile, vaccinations continue even as the new administration settles in. Operation Warp Speed officials previously said the states were able to obtain roughly 4 million doses per week, but that manufacturing was ramping up.

Former chief adviser Moncef Slaoui told CBS that both Pfizer (PFE) and Moderna (MRNA) are now producing 30 million doses per month.

But how the federal government and the new administration will engage and help speed up production and administration remains to be seen.

The WHO, meanwhile, is poised to approve several vaccine options globally, including those from China, Russia, and India.

New faces in town

New U.S. Centers for Disease Control and Prevention (CDC) director Dr. Rochelle Walensky took the helm of the agency Wednesday, a position that does not require Senate confirmation.