Asian stocks lose footing on renewed China jitters
Johannes Eisele | AFP | Getty Images. Asian equities declined early Wednesday, taking the cues from hefty losses in offshore markets. · CNBC

Asian equities slid deeper into the red on Wednesday, after a preliminary reading of China's mammoth manufacturing sector fell to a six-and-a-half-year low of 47.0 in September, rekindling worries over the world's second-largest economy.

The downbeat sentiment persisted even as Chinese President Xi Jinping defended his country's growth pace and reassured the world that China's financial markets will remain stable in his first policy address during a state visit to the United States.

"The flash China PMI fell more than market participants [had] expected and the PMI is also well below the 50-point threshold, which reaffirms that Chinese economic activity continues to slow and this adding to global economic and financial concerns," Elias Haddad, senior currency strategist at Commonwealth Bank of Australia, told CNBC Asia's " Street Signs ."

An unimpressive handover from offshore markets also weighed on Asian bourses.

Major U.S. averages crashed more than 1 percent overnight, with materials shares among the hardest-hit due to a sell-off in commodities on the back of lingering worries about a slower-growing China.

News that Volkswagen (XETRA:VOW3-DE) would make a provision of $7.3 billion after allegations it cheated on vehicle emission tests sparked a global selloff in auto stocks. The Nasdaq Biotech Index also extended losses into a second day after U.S. Democratic presidential candidate Hillary Clinton said she would propose a monthly cap of $250 on prescription drugs.

Across the pond, the pan-European STOXX 600 (^STOXX) finished the day significantly lower, down 3.1 percent as autos tanked and weaker oil prices weighing on investor sentiment.

Meanwhile, markets in Japan remain shuttered for the Autumn Equinox holiday and are set to reopen Thursday.

China indices tumble

China's Shanghai Composite index lurched lower in the final 30 minutes of trading to close down 2.2 percent, with the selling concentrated among blue chips on Wednesday.

Brokerage houses surrendered Tuesday's advances; Citic Securities (Shanghai Stock Exchange: 30-SZ), Haitong Securities (Shanghai Stock Exchange: 837-SZ) and China Merchants Securities lost more than 4 percent each.

Banking shares also lost ground, with Bank of China (Shanghai Stock Exchange: 1988-SZ) and Industrial and Commercial Bank of China (Shanghai Stock Exchange: 1398-SZ) (ICBC) declining more than 1 percent each, while PetroChina (Shanghai Stock Exchange: 1857-SZ) which has the heaviest weighting of any Chinese company in the Shanghai index, crashed down 2.1 percent.

Among other indexes, the benchmark CSI300 Index tanked 2.3 percent. Small-caps got off lightly on comparison; the Shenzhen Composite notched down 0.8 percent while the start-up board ChiNext erased losses to tick up 0.2 percent.