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UPDATE 5-ECB eyes jumbo rate hike to fight inflation even as debtors suffer

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75 bps rate hike in Oct in focus

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German inflation 10.9% in Sept vs 8.8% in Aug

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Running down bond portfolio appears most contentious

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Inflation in Sept to hit new record high

(Adds Lane's comment, material from sources)

By Francesco Canepa and Balazs Koranyi

VILNIUS/FRANKFURT, Sept 29 (Reuters) - ECB policymakers voiced more support on Thursday for another big interest rate hike as inflation in the euro zone's biggest economy hit double digits, blasting past expectations and heralding another record reading for the bloc as a whole.

The European Central Bank has raised rates by a combined 125 basis points over its last two meetings and promised further increases as sky-high food and energy prices filter into the rest of the economy and intensify underlying price pressures.

Strengthening the case for another 75 basis point increase, German inflation jumped to 10.9% this month, far beyond expectations for a reading of 10%. That suggests the figure for the wider 19-country euro zone, due on Friday, is also likely to exceed the predicted 9.6%.

"My choice would be 75 (basis points)," ECB policymaker Gediminas Simkus told Bloomberg TV on the sidelines of a conference in Vilnius "But 50 is the minimum."

Colleagues including Slovakia's Peter Kazimir, Austria's Robert Holzmann and Finland's Olli Rehn have all put 75 basis points on the table in recent days, even though the ECB's next meeting on Oct. 27 is still nearly a month away.

But Simkus, like Holzmann a day earlier, pushed back on suggestions of a 100 basis point move, suggesting that a repeat of this month's 75 basis point hike is the upper limit of hawks' appetite even if price pressures are far from abating.

Speaking later on CNBC, ECB chief economist Philip Lane said the central bank should avoid doing "too much in one go" and increase rates over several months after what he described as "sizeable moves" in the last two meetings.

"There is no easing in sight, and next year the inflation rate is only likely to fall because energy prices are unlikely to rise again as strongly as this year, partly due to government intervention," Commerzbank economist Ralph Solveen said of the German inflation figures.

While few governors ventured to estimate where interest rate hikes could end, Spain's Pablo Hernandez de Cos said on Thursday that models suggest a significantly lower terminal rate than markets now expect.

"On the basis of current information, the median terminal rate value across models is at 2.25%-2.50%," de Cos said.