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UPDATE 8-Ethnic Armenians flee Karabakh after breakaway region's defeat

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Over 6,000 flee Karabakh, jamming roads

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Russia tells Armenian PM: you are making a big mistake

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Senior US officials travel to Armenia

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Turkey's Erdogan meets Azerbaijan's Aliyev

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To discuss Karabakh, gas and Nakhchivan

(Adds explosion at fuel depot, paragraphs 4-5)

STEPANAKERT-KHANKENDI, Azerbaijan, Sept 25 (Reuters) - T housands of ethnic Armenians fled the breakaway region of Nagorno-Karabakh on Monday, queuing up for fuel and jamming the mountain road to Armenia after their fighters were defeated by Azerbaijan in a lightning military operation.

The leadership of the 120,000 Armenians who call Karabakh home told Reuters on Sunday that they did not want to live as part of Azerbaijan and that they would leave for Armenia because they feared persecution and ethnic cleansing.

In the Karabakh capital, known as Stepanakert by Armenia and Khankendi by Azerbaijan, crowds of people were loading belongings into buses and trucks as they left for Armenia.

The mass departures were marked by confusion.

An explosion at a gas storage depot on a road outside the capital injured more than 200 people, local news reports said, quoting Nagorno-Karabakh's ombudsman Gegham Stepanyan. Most of the injured were in serious or very serious condition and needed to be taken out of the region urgently for treatment, Stepanyan said.

Refugees who reached Armenia told Reuters they believed the history of their breakaway state was finished.

"No one is going back - that's it," Anna Agopyan, who reached Goris, a border town in Armenia, told Reuters. "The topic of Karabakh is over now for good, I think."

U.S. President Joe Biden said in a letter delivered to Armenian Prime Minister Nikol Pashinyan by U.S. Agency for International Development (USAID) chief Samantha Power that the United States would help address the humanitarian needs.

"You are aware that, unfortunately, the process of ethnic cleansing of the Armenians of Nagorno-Karabakh continues, it is happening right now, and it is a very tragic fact," Pashinyan told Power, according to an Armenian government transcript.

Azerbaijan, which has repeatedly denied any claims of ethnic cleansing, said that the rights of Armenians in Karabakh, a territory internationally recognised as part of Azerbaijan, would be guaranteed.

But thousands of ethnic Armenians have already left. The Armenian government said at least 6,650 people from Nagorno-Karabakh had crossed into Armenia, up from about 4,850 people five hours earlier.

The ethnic Armenian leadership said it would remain in place until all those who wanted to leave what they call Artsakh were able to go. They urged residents to hold back from crowding the roads out but promised free fuel to all those who were leaving.