OSE Immunotherapeutics Announces Publication of Preclinical Efficacy Results with Lusvertikimab in Acute Lymphoblastic Leukemia in the Journal ‘Blood’

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OSE Immunotherapeutics
OSE Immunotherapeutics

OSE Immunotherapeutics Announces Publication of Preclinical Efficacy Results with Lusvertikimab in
Acute Lymphoblastic Leukemia in the Journal ‘Blood’

Nantes, France – July 1st, 2024 – 7:30 am CET – OSE Immunotherapeutics SA (ISIN: FR0012127173; Mnemo: OSE) today announced the publication of an article on latest preclinical efficacy data on the use of its anti-IL-7 receptor (IL-7R

A&io) antagonist Lusvertikimab (OSE-127) for the treatment of B- and T-Cell Acute Lymphoblastic Leukemia (B- and T-ALL) in ‘Blood’, a peer-reviewed medical journal published by the American Society of Hematology.

The preclinical data on Lusvertikimab published in ‘Blood’ was generated from a collaborative research program between OSE Immunotherapeutics and the University Medical Center Schleswig-Holstein in Kiel (Germany). This collaboration is using patient-derived samples and in-vivo xenograft models to evaluate the therapeutic potential of anti-IL-7R antagonist Lusvertikimab in targeting and blocking the high and dysregulated IL-7R-expression observed in nearly 85% of B- or T-Acute Lymphoblastic Leukemia (ALL) patients.

Pr. Denis Schewe (newly appointed Head of Pediatric Hematology/Oncology, University Hospital Dresden and National Center for Tumor Diseases, Partner Site Dresden, and formerly from the University Medical Center Schleswig-Holstein of Kiel) and Dr. Lennart Lenk (Department of Pediatrics I, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel), leading the research program in collaboration with OSE Immunotherapeutics, comment: “Treatment options for T-ALL remain very limited and there is an urgent need for novel immunotherapy approaches to reduce toxicity and to target relapsed or refractory disease in ALL patients. Through its dual mode of action comprising both IL-7R signaling blockade and antibody-dependent cellular phagocytosis induction, Lusvertikimab may represent a promising novel immunotherapy option for CD127 positive ALL patients, particularly in combination with polychemotherapy standard of care. When translated into the clinic, Lusvertikimab could significantly improve ALL-therapy and the outcome of relapsed/refractory disease.”

Nicolas Poirier, Chief Executive Officer of OSE Immunotherapeutics, concludes: “We are very pleased with this publication on Lusvertikimab in ‘Blood’, a high-level journal within the field of hematology whose manuscripts are reviewed by prominent specialists. Novel targeted immunotherapy options are urgently needed for B-ALL and T-ALL patients and we are happy to collaborate with the research leaders in hematology from the University of Kiel to face this clinical challenge.”