Hemostemix Closes its Funded Manufacturing Services Agreement with CytoImmune, Restarting Production of ACP-01

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Calgary, Alberta--(Newsfile Corp. - August 1, 2024) - Hemostemix Inc. (TSXV: HEM) (OTC Pink: HMTXF) (FSE: 2VF0) is pleased to announce it and CytoImmune Therapuetics ("CytoImmune") today signed a binding and funded definitive Manufacturing Services Agreement that re-establishes production of ACP-01 ("ACP") in CytoImmune's state-of-the-art clinical cell manufacturing facility in Toa Baja, Puerto Rico.

CytoImmune Therapeutics, Toa Baja, Puerto Rico

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Hemostemix and CytoImmune have successfully completed the initial setup of the manufacturing facility and are on track to produce the first ACP-01 therapy by Q1 2025. A renewable two year agreement, the contract is fully funded by the issuance to CytoImmune of 30,140,000 x $0.05 Common Shares of Hemostemix Inc. Additionally, the agreement funds the production of the first 22 ACP-01 commercial therapies, which Hemostemix will sell for $1,100,000 ($50,000 each).

ACP-01 is a safe and effective stem cell solution for patients suffering from cardiovascular disease who have no other treatment options. It regenerates circulation where the body signals that need, improving heart function by 27%, as supported by clinical data.

"We are very pleased to partner with CytoImmune, to re-establish production, to help no-option patients while generating significant net cash flow for our shareholders," stated Thomas Smeenk, CEO. "At the initial sales levels, Hemostemix becomes self-funding with respect to future development of our autologous platform technologies," Smeenk stated.

"We are thrilled to be delivering on our promise to Puerto Rico and advancing the production of ACP-01. This partnership with Hemostemix marks a significant milestone for CytoImmune as we expand our cell therapy capabilities. By leveraging our state-of-the-art facility and expert team, we aim to provide life-changing treatments to patients with cardiovascular diseases and other severe conditions. Our commitment to innovation and patient care drives us to continually improve our processes and explore new opportunities for growth," stated CytoImmune's CEO Jose E. Vidal, PhD.

Looking ahead, the companies are exploring additional collaborations for phase 1 clinical trials in Puerto Rico that qualify for 50% cash reimbursement of trial expenses under PR's Technology and Inovation incentives, followed by phase II trials in North America and Europe.