Could That Old Mole Be Skin Cancer?

Most adults have between 10 and 40 moles—which are small clusters of pigment-producing skin cells. Some people, especially those with lighter skin, may have many more. Those moles may change in size and appearance over the years, and in rare instances, a mole may become a melanoma, the most potentially deadly skin cancer.

But if you’re like most people, you don’t examine your moles or have a doctor check them periodically to see whether changes may signal a possible skin cancer. In fact, a survey of 476 people published in The Journal of Clinical and Aesthetic Dermatology found that only 25 percent reported checking their skin monthly and 17 percent reported that they did it just once a year.

That may be due, in part, to confusion over how effective regular skin checks are at finding possible skin cancers. So should you or a dermatologist check your skin? If so, how often? Here’s what you need to know about changing moles and skin cancer risk:

Can All Moles Cause Skin Cancer?

Common moles are those we’re born with or develop until about age 40. They can change or even disappear over the years, and very rarely become skin cancers. But according to the National Cancer Institute, having 50 or more puts people at higher risk of melanoma­—although brand-new research published in JAMA Dermatology has called that into question.

So-called atypical moles often appear during puberty but can pop up throughout life. They’re considered benign (not skin cancers) but may have some features of melanoma, such as irregular borders.

Most atypical moles don’t become melanomas, but they are more likely than common moles to become cancerous. Having five or more atypical moles is linked to a higher than normal risk of “thick,” or more advanced, melanoma. (Many melanomas start as pigmented moles, but the two more common skin cancers, basal cell and squamous cell carcinoma, don’t. They arise on their own from normal skin.)

The mechanism behind a mole’s change from benign to cancerous may be genetic in some cases. And though melanoma can occur in areas that are usually shielded from sunlight, ultraviolet radiation seems to be a significant factor. In a study published in the New England Journal of Medicine, Boris C. Bastian, M.D., Ph.D., professor of dermatology and pathology at the University of California, San Francisco, and colleagues found that a mole exposed to UV radiation (like that from the sun or tanning beds) can mutate, triggering the abnormally rapid cell division that characterizes cancer.

Pros and Cons of Checking for Skin Cancer